Lactoferrin-tethered betulinic acid nanoparticles promote rapid delivery and cell death in triple negative breast and laryngeal cancer cells
| العنوان: | Lactoferrin-tethered betulinic acid nanoparticles promote rapid delivery and cell death in triple negative breast and laryngeal cancer cells |
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| المؤلفون: | Suvadra Das, Arup Mukherjee, Urmi Chatterji, Asim Halder, Megha Jethwa, Partha Roy, A. B. M. Helal Uddin, Subarna Ghosh, Pritha Mukherjee |
| المصدر: | Artificial Cells, Nanomedicine, and Biotechnology. 48:1362-1371 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Programmed cell death, Cell Survival, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Antineoplastic Agents, Apoptosis, Triple Negative Breast Neoplasms, 02 engineering and technology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Betulinic acid, Humans, Medicine, Particle Size, Betulinic Acid, Laryngeal Neoplasms, Triple negative, Triple-negative breast cancer, Cell Proliferation, Drug Carriers, biology, Lactoferrin, business.industry, Cell Cycle, General Medicine, 021001 nanoscience & nanotechnology, chemistry, Cell culture, 030220 oncology & carcinogenesis, Cancer cell, Cancer management, Cancer research, biology.protein, Nanoparticles, Pentacyclic Triterpenes, 0210 nano-technology, business, Biotechnology |
| الوصف: | Cancer management presents multifarious problems. Triple negative breast cancer (TNBC) is associated with inaccurate prognosis and limited chemotherapeutic options. Betulinic acid (BA) prevents angiogenesis and causes apoptosis of TNBC cells. NIH recommends BA for rapid access in cancer chemotherapy because of its cell-specific toxicity. BA however faces major challenges in therapeutic practices due to its limited solubility and cellular entree. We report lactoferrin (Lf) attached BA nanoparticles (Lf-BAnp) for rapid delivery in triple negative breast (MDA-MB-231) and laryngeal (HEp-2) cancer cell types. Lf association was confirmed by SDS-PAGE and FT-IR analysis. Average hydrodynamic size of Lf-BAnp was 147.7 ± 6.20 nm with ζ potential of -28.51 ± 3.52 mV. BA entrapment efficiency was 75.38 ± 2.70% and the release mechanism followed non-fickian pattern. Impact of Lf-BAnp on cell cycle and cytotoxicity of triple negative breast cancer and its metastatic site laryngeal cancer cell lines were analyzed. Lf-BAnp demonstrated strong anti-proliferative and cytotoxic effects, along with increased sub-G |
| تدمد: | 2169-141X 2169-1401 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd98d2c9eccaa5bf244033abed7c769Test https://doi.org/10.1080/21691401.2020.1850465Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7cd98d2c9eccaa5bf244033abed7c769 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2169141X 21691401 |
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