Association between EZH2 expression, silencing of tumor suppressors and disease outcome in solid tumors
| العنوان: | Association between EZH2 expression, silencing of tumor suppressors and disease outcome in solid tumors |
|---|---|
| المؤلفون: | Audrey Michaud, Michel Wassef, Raphaël Margueron |
| المصدر: | Cell Cycle |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, tumor suppressor, macromolecular substances, Models, Biological, law.invention, Mice, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, law, Prostate, Neoplasms, Biomarkers, Tumor, medicine, Animals, Humans, Gene silencing, Enhancer of Zeste Homolog 2 Protein, Genes, Tumor Suppressor, Gene Silencing, EZH2, Molecular Biology, Cyclin-Dependent Kinase Inhibitor p16, breast, Cell Line, Transformed, Cell Proliferation, Extra Views, prostate, biology, Cell growth, Cell Biology, solid tumors, PRC2, Polycomb, Treatment Outcome, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, Cancer cell, biology.protein, Cancer research, Suppressor, prognosis, Developmental Biology |
| الوصف: | EZH2, the main catalytic component of the Polycomb Repressive Complex 2 (PRC2) is apparently upregulated in most solid tumors. Furthermore its expression generally associates with poor prognosis. It was proposed that this correlation reflects a causal event, EZH2 mediating the silencing of key tumor suppressor loci. In contrast, we recently showed that EZH2 is dispensable for solid tumor development and that its elevated expression reflects the abnormally high proliferation rate of cancer cells. Here, we investigate the functional association between EZH2 expression and silencing of key tumor suppressor loci and further illustrate the confounding effect of proliferation on EZH2′s association to outcome. |
| تدمد: | 1551-4005 1538-4101 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312f437642b1299704816b9d7dce6007Test https://doi.org/10.1080/15384101.2016.1208872Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....312f437642b1299704816b9d7dce6007 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15514005 15384101 |
|---|