Pancreatic cancer surgery in elderly patients: Balancing between short-term harm and long-term benefit. A population-based study in the Netherlands
| العنوان: | Pancreatic cancer surgery in elderly patients: Balancing between short-term harm and long-term benefit. A population-based study in the Netherlands |
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| المؤلفون: | Valery E.P.P. Lemmens, Koert P. de Jong, Ignace H. J. T. de Hingh, I. Quintus Molenaar, Lydia G. M. van der Geest, Olivier R. Busch, Yvette R. B. M. van Gestel, Marc G. Besselink |
| المساهمون: | Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, Surgery, Groningen Institute for Organ Transplantation (GIOT), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Public Health |
| المصدر: | Acta oncologica (Stockholm, Sweden), 55(3), 278-285. Informa Healthcare ACTA ONCOLOGICA, 55(3), 278-285. Taylor & Francis Ltd Acta Oncologica, 55(3), 278-285. Informa Healthcare |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, IMPACT, medicine.medical_treatment, 030230 surgery, Logistic regression, 0302 clinical medicine, Duodenal Neoplasms, Periampullary cancer, Young adult, Netherlands, Aged, 80 and over, OUTCOMES, Hematology, General Medicine, Middle Aged, Prognosis, Pancreaticoduodenectomy, people.cause_of_death, Survival Rate, Oncology, 030220 oncology & carcinogenesis, PANCREATICODUODENECTOMY, Adenocarcinoma, Female, Adult, Ampulla of Vater, medicine.medical_specialty, RESECTION, POSTOPERATIVE MORTALITY, Young Adult, 03 medical and health sciences, AGE, Pancreatectomy, SDG 3 - Good Health and Well-being, Pancreatic cancer, CENTRALIZATION, medicine, Humans, Radiology, Nuclear Medicine and imaging, OLDER-ADULTS, Survival rate, Aged, Neoplasm Staging, business.industry, OCTOGENARIANS, medicine.disease, Surgery, Cancer registry, Pancreatic Neoplasms, Neoplasm Grading, Neoplasm Recurrence, Local, business, people, Follow-Up Studies |
| الوصف: | Background: At a national level, it is unknown to what degree elderly patients with pancreatic or periampullary carcinoma benefit from surgical treatment compared to their younger counterparts. We investigated resection rates and outcomes after surgical treatment among elderly patients. Methods: From the Netherlands Cancer Registry, 20 005 patients diagnosed with primary pancreatic or periampullary cancer in 2005-2013 were selected. The associations between age (= 80 years) and resection rates were investigated using chi(2) tests, and surgical outcomes (30-, 90-day mortality) were evaluated using logistic regression analysis. Overall survival after resection was investigated by means of Kaplan-Meier and Cox proportional hazard regression analysis. Results: During the study period, resection rates increased in all age groups (= 80 years: 2-8%, p < 0.001). Of 3845 patients who underwent tumour resection for pancreatic or periampullary carcinoma, the proportion of octogenarians increased from 3.5% to 5.5% (p = 0.03), whereas postoperative mortality did not increase (30-day: 6-3%, p = 0.06; 90-day: 9-8%, p = 0.21). With rising age, 30-day postoperative mortality increased (4-5-7-8%, respectively, p < 0.001), while 90-day mortality was 6-10-13-12% (p < 0.001) and three-year overall survival rates after surgery were 35-33-28-31%, respectively (p < 0.001). After adjustment for confounding factors, octogenarians who survived 90 days postoperative exhibited an overall survival close to younger patients [hazard ratio (>= 80 vs. |
| تدمد: | 1651-226X 0284-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b73219228c9043a60a75a270b23699Test https://doi.org/10.3109/0284186x.2015.1105381Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d2b73219228c9043a60a75a270b23699 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1651226X 0284186X |
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