Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
| العنوان: | Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice |
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| المؤلفون: | Peng Zhao, Yuanzhong Xu, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Qingchun Tong, Ningyan Zhang, Zhiqiang An |
| المصدر: | mAbs. 14 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Amyloid beta-Peptides, Membrane Glycoproteins, Immunology, Infant, Mice, Transgenic, Plaque, Amyloid, Disease Models, Animal, Mice, Alzheimer Disease, Receptors, Transferrin, Animals, Humans, Syk Kinase, Immunology and Allergy, Microglia, Receptors, Immunologic |
| الوصف: | Triggering receptor expressed on myeloid cells 2 (TREM2) plays a crucial role in regulating microglial functions and removal of amyloid plaques in Alzheimer's disease (AD). However, therapeutics based on this knowledge have not been developed due to the low antibody brain penetration and weak TREM2 activation. In this study, we engineered a TREM2 bispecific antibody to potently activate TREM2 and enter the brain. To boost TREM2 activation, we increased the valency of bivalent anti-TREM2 Ab2 IgG to tetra-variable domain immunoglobulin (TVD-Ig), thus improving the EC |
| تدمد: | 1942-0870 1942-0862 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e132dee51e09afd6bffcdcb3ef3ad98Test https://doi.org/10.1080/19420862.2022.2107971Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0e132dee51e09afd6bffcdcb3ef3ad98 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420870 19420862 |
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