Clinical, neuroimaging, and neuropathological characterization of a patient with Alzheimer’s disease syndrome due to Pick’s pathology
| العنوان: | Clinical, neuroimaging, and neuropathological characterization of a patient with Alzheimer’s disease syndrome due to Pick’s pathology |
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| المؤلفون: | Paul Sukhanov, Bruce L. Miller, Jennifer Zitser, Joel H. Kramer, Howard J. Rosen, Lea T. Grinberg, Katherine P. Rankin, Gianina Toller, Harli Grant |
| المصدر: | Neurocase |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Neuroimaging, Disease, Article, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Pick Disease of the Brain, Arts and Humanities (miscellaneous), Alzheimer Disease, Humans, Medicine, Memory impairment, Dementia, 030304 developmental biology, 0303 health sciences, business.industry, Syndrome, Frontotemporal lobar degeneration, medicine.disease, 3. Good health, Frontotemporal Dementia, Pick's disease, Neurology (clinical), business, 030217 neurology & neurosurgery, Frontotemporal dementia |
| الوصف: | The most common neurodegenerative syndrome associated with Pick’s disease pathology (PiD), a type of frontotemporal lobar degeneration, is behavioral variant frontotemporal dementia (bvFTD), which is characterized by profound changes in social behavior. However, in rare cases, PiD can manifest as an Alzheimer’s disease-type dementia featuring early impairment of episodic memory. We describe the longitudinal cognitive and socioemotional changes as well as the structural imaging and neuropathological findings of a patient who presented with late-onset AD-type dementia with PiD. The patient showed slowly progressive episodic memory impairment, followed by executive dysfunctions and changes in social behavior, but preserved visuospatial, language, and motor functions. Consistent with this clinical profile, gray matter atrophy and underlying PiD were most predominantly found in anterior temporal and frontal lobe regions of the salience and semantic-appraisal networks, with relative sparing of language-related temporal lobe structures and parietal areas involved in visuospatial functioning. Our findings from this patient presenting with memory complaints suggest that early bvFTD-like social symptoms such as loss of empathy and disinhibition as well as slow disease progression and paucity of motor symptoms are key clinical features suggestive of a frontotemporal lobar degeneration pathology like PiD. This case report may help improve the ability of clinicians and clinical researchers to predict the pathology of patients with atypical presentations of AD, which will ultimately be critical for enrollment of patients into disease-modifying clinical trials targeting the underlying proteinopathy. |
| تدمد: | 1465-3656 1355-4794 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9089c0ab8d45497484678bac6e132a8dTest https://doi.org/10.1080/13554794.2021.1936072Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9089c0ab8d45497484678bac6e132a8d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14653656 13554794 |
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