BMI but not age and sex negatively impact on the outcome of pharmacotherapy in fibromyalgia: a systematic review
| العنوان: | BMI but not age and sex negatively impact on the outcome of pharmacotherapy in fibromyalgia: a systematic review |
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| المؤلفون: | Markus Tingart, Nicola Maffulli, Jörg Eschweiler, Giorgia Colarossi, Filippo Migliorini, Arne Driessen |
| المصدر: | Expert Review of Clinical Pharmacology. 14:1029-1038 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Fibromyalgia, Pharmacological management, Age and sex, Severity of Illness Index, 030226 pharmacology & pharmacy, Body Mass Index, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Pharmacotherapy, Humans, Medicine, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Randomized Controlled Trials as Topic, business.industry, Age Factors, nutritional and metabolic diseases, General Medicine, medicine.disease, Treatment Outcome, 030220 oncology & carcinogenesis, Physical therapy, business, Body mass index |
| الوصف: | The impact of sex, age, body mass index (BMI) in fibromyalgia is still unclear. A systematic review was conducted to investigate whether sex, age and BMI influence the clinical outcomes and rate of adverse events.The present study was performed according to the PRISMA guidelines. The literature search was performed in February 2021. All the RCTs investigating pharmacological strategies for fibromyalgia were accessed.Data from 51 RCTs (17,311 patients) were collected. Short Form 36 emotional, Social function and physical role subscales showed evidence of a negative association with BMI (P = 0.02, P = 0.002 and P = 0.0001, respectively). Depression and anxiety subscales of the Hospital Anxiety and Depression score demonstrated evidence of a positive association with age (P = 0.04 and P = 0.001, respectively) and sex (P = 0.00005 and P = 0.0001, respectively). Visual analog scale evidenced a positive association with BMI (P = 0.04). Clinical Global Impression Severity scale demonstrated evidence of a negative association with BMI (P = 0.02).Irrespective from the pharmacological approach, a higher BMI is negatively associated with a favorable outcome in patients with fibromyalgia. The association with sex and age remains controversial.I, systematic review of RCTs. |
| تدمد: | 1751-2441 1751-2433 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6c4551c47d90eaa6e284d54825a3ccTest https://doi.org/10.1080/17512433.2021.1929923Test |
| رقم الانضمام: | edsair.doi.dedup.....fa6c4551c47d90eaa6e284d54825a3cc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17512441 17512433 |
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