The Small GTPase Ral orchestrates MVB biogenesis and exosome secretion
| العنوان: | The Small GTPase Ral orchestrates MVB biogenesis and exosome secretion |
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| المؤلفون: | Michel Labouesse, Vincent Hyenne, Jacky G. Goetz |
| المساهمون: | Forces mécaniques et morphogénèse des tissus = Mechanical forces behind tissue morphogenesis (LBD-E08), Laboratoire de Biologie du Développement (LBD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Small GTPases Small GTPases, 2016, pp.1-7. ⟨10.1080/21541248.2016.1251378⟩ Small GTPases, Taylor & Francis, 2016, pp.1-7. ⟨10.1080/21541248.2016.1251378⟩ |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Endosome, Cell Membrane, Multivesicular Bodies, macromolecular substances, Cell Biology, Extracellular vesicle, Biology, Exosomes, Biochemistry, Exosome, Microvesicles, Cell biology, ESCRT complex, 03 medical and health sciences, 030104 developmental biology, Animals, Commentary - Commissioned, ral GTP-Binding Proteins, Small GTPase, Secretion, Caenorhabditis elegans, [SDV.BDD]Life Sciences [q-bio]/Development Biology, ComputingMilieux_MISCELLANEOUS, Biogenesis |
| الوصف: | Extracellular vesicles are novel mediators of cell-cell communication. They are present in all species and involved in physiological and pathological processes. One class of extracellular vesicles, the exosomes, originate from an endosomal compartment, the MultiVesicular Body (MVB), and are released from the cell upon fusion of the MVB with the plasma membrane. Although different molecular mechanisms have been associated with MVB biogenesis and exosome secretion, how they coordinate remains poorly documented. We recently found that the small GTPase Ral contributes to exosome release in nematodes and mammalian tumor cells. More specifically, we found that C. elegans RAL-1 is required for the biogenesis of MVBs, and later for MVB fusion with the plasma membrane. Here, we discuss our results in relationship with other factors involved in extracellular vesicle production such as the ESCRT complex and Phospholipase 1D. We propose models to explain Ral function in exosome secretion, its conservation in animals, and its possible role in tumor progression. |
| تدمد: | 2154-1256 2154-1248 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f510a7993978aec9a7287e32e0e185e1Test https://doi.org/10.1080/21541248.2016.1251378Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f510a7993978aec9a7287e32e0e185e1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21541256 21541248 |
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