Soyasaponins Prevent H2O2-Induced Inhibition of Gap Junctional Intercellular Communication by Scavenging Reactive Oxygen Species in Rat Liver Cells
| العنوان: | Soyasaponins Prevent H2O2-Induced Inhibition of Gap Junctional Intercellular Communication by Scavenging Reactive Oxygen Species in Rat Liver Cells |
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| المؤلفون: | Hai-Ji Luo, Suxia Sun, Longying Zha, Limei Mao, Dingsheng Zha, Jiguo Wu, Hong Deng, Xinwei Chu, Jiading Chen |
| المصدر: | Nutrition and Cancer. 66:1342-1351 |
| بيانات النشر: | Informa UK Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Cancer Research, Reactive oxygen species, Nutrition and Dietetics, Liver cytology, Medicine (miscellaneous), Biology, medicine.disease_cause, Cell biology, Comet assay, chemistry.chemical_compound, Oncology, chemistry, Biochemistry, Cell culture, medicine, Tumor promotion, Hydrogen peroxide, Carcinogenesis, Intracellular |
| الوصف: | It appears to be more practical and effective to prevent carcinogenesis by targeting the tumor promotion stage. Gap junctional intercellular communication (GJIC) is strongly involved in carcinogenesis, especially the tumor promotion stage. Considerable interest has been focused on the chemoprevention activities of soyasaponin (SS), which are major phytochemicals found in soybeans and soy products. However, less is known about the preventive effects of SS (especially SS with different chemical structures) against tumor promoter-induced inhibition of GJIC. We investigated the protective effects of SS-A1, SS-A2, and SS-I against hydrogen peroxide (H2O2)-induced GJIC inhibition and reactive oxygen species (ROS) production in Buffalo rat liver (BRL) cells. The present results clearly show for the first time that SS-A1, SS-A2, and SS-I prevent the H2O2-induced GJIC inhibition by scavenging ROS in BRL cells in a dose-dependent manner at the concentration range of from 25 to 100 μg/mL. Soyasaponins attenuated the... |
| تدمد: | 1532-7914 0163-5581 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::09cf6681e4bb649bfe62bdc3ed2f82d3Test https://doi.org/10.1080/01635581.2014.956245Test |
| رقم الانضمام: | edsair.doi...........09cf6681e4bb649bfe62bdc3ed2f82d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15327914 01635581 |
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