Considerations in sirolimus use in the early and late post-transplant periods
| العنوان: | Considerations in sirolimus use in the early and late post-transplant periods |
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| المؤلفون: | Erin N. Elliott, Lillian W. Gaber, Samir J. Patel, Richard J. Knight, A. Osama Gaber |
| المصدر: | Expert Opinion on Drug Safety. 8:421-434 |
| بيانات النشر: | Informa UK Limited, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Graft Rejection, Time Factors, Pharmacology, Tacrolimus, Pharmacotherapy, Chronic allograft nephropathy, Humans, Medicine, Pharmacology (medical), Postoperative Period, cardiovascular diseases, Dosing, Adverse effect, Sirolimus, Clinical Trials as Topic, business.industry, General Medicine, equipment and supplies, medicine.disease, Kidney Transplantation, Transplantation, Calcineurin, surgical procedures, operative, Concomitant, Cyclosporine, cardiovascular system, Drug Therapy, Combination, Kidney Diseases, business, Immunosuppressive Agents, medicine.drug |
| الوصف: | Sirolimus is an antiproliferative immunosuppressive agent that inhibits the mammalian target of rapamycin. It is highly effective in preventing acute renal allograft rejection and can be used with either calcineurin inhibitors, antimetabolites or corticosteroids. Early studies in renal transplantation have provided insight into optimal dosing strategies of sirolimus and of concomitant immunosuppressive agents. Familiarity with the adverse effect profile of sirolimus and pharmacokinetic and dynamic interactions with other immunosuppressive agents allows for earlier recognition and better management of sirolimus-related complications. The role of sirolimus in preserving long-term renal function, post-transplant malignancies and in prevention of atherosclerosis is currently being considered. |
| تدمد: | 1744-764X 1474-0338 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ec7784b32f2415c1bd6d2b5dae1a32Test https://doi.org/10.1517/14740330903037156Test |
| رقم الانضمام: | edsair.doi.dedup.....a3ec7784b32f2415c1bd6d2b5dae1a32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1744764X 14740338 |
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