Functional involvement of the cerebral cortex following paramedian bithalamic infarction
| العنوان: | Functional involvement of the cerebral cortex following paramedian bithalamic infarction |
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| المؤلفون: | Stefan Golaszewski, Gunther Ladurner, Frediano Tezzon, Raffaele Nardone, Jürgen Bergmann, Martin Kronbichler, Pierpaolo De Blasi, Francesca Caleri |
| المصدر: | Neurocase. 16:286-292 |
| بيانات النشر: | Informa UK Limited, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_treatment, psychic self-activation, Thalamus, Stimulation, Bithalamic infarction, Arts and Humanities (miscellaneous), Cortex (anatomy), Reaction Time, medicine, Humans, Cerebral Cortex, transcranial magnetic stimulation cortical silent period, short latency intracortical inhibition, short latency afferent inhibition, Human brain, Middle Aged, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, medicine.anatomical_structure, Infarction, Cerebral cortex, Cholinergic, Female, Silent period, Neurology (clinical), Psychology, Neuroscience |
| الوصف: | To investigate further the functional mechanisms underlying the so-called 'loss of psychic self-activation' following paramedian bithalamic lesions, we used transcranial magnetic stimulation (TMS) in a patient who presented with this clinical picture after paramedian bithalamic infarction due to arterial occlusion. The patient showed higher motor thresholds than the controls; the cortical silent period and intracortical inhibition to paired-pulse stimulation, two different forms of inhibition that are believed to reflect GABAergic mechanisms, were significantly increased; short latency afferent inhibition (SAI), a technique that may give direct information about the function of some cholinergic circuits in the human brain, was significantly reduced. This study first demonstrates that there are changes in the intracortical excitatory and inhibitory circuits in this neurobehavioral syndrome, that lead to cortical hypoexcitability. The modulation in GABAergic activity may result in excitability changes in those cholinergic cortical networks that are involved in SAI. TMS may provide important information on connections between the thalamus and cortex and may help in better understanding the role of the thalamo-cortical relationship in behavioural changes associated with thalamic stroke. |
| تدمد: | 1465-3656 1355-4794 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c36a1ec8de820b087fcc7b55a0c81aTest https://doi.org/10.1080/13554790903463593Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d4c36a1ec8de820b087fcc7b55a0c81a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14653656 13554794 |
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