Vaccines against gastroenteritis, current progress and challenges
| العنوان: | Vaccines against gastroenteritis, current progress and challenges |
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| المؤلفون: | Qiangde Duan, Hyesuk Seo, Weiping Zhang |
| المصدر: | Gut Microbes Gut Microbes, Vol 11, Iss 6, Pp 1486-1517 (2020) |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Salmonella, norovirus, enterotoxigenic escherichia coli (etec), Review, Biology, medicine.disease_cause, Microbiology, 03 medical and health sciences, 0302 clinical medicine, multiepitope fusion antigen (mefa), Drug Development, Enterotoxigenic Escherichia coli, Rotavirus, medicine, Animals, Humans, Shigella, lcsh:RC799-869, Pathogen, Campylobacter, Gastroenterology, campylobacter, Viral Vaccines, vibrio cholerae, medicine.disease, Cholera, Virology, Gastroenteritis, shigella, nontyphoidal salmonella, rotavirus, 030104 developmental biology, Infectious Diseases, Bacterial Vaccines, Norovirus, enteric diseases, vaccinology, lcsh:Diseases of the digestive system. Gastroenterology, 030211 gastroenterology & hepatology |
| الوصف: | Enteric viral and bacterial infections continue to be a leading cause of mortality and morbidity in young children in low-income and middle-income countries, the elderly, and immunocompromised individuals. Vaccines are considered an effective and practical preventive approach against the predominantly fecal-to-oral transmitted gastroenteritis particularly in the resource-limited countries or regions where implementation of sanitation systems and supply of safe drinking water are not quickly achievable. While vaccines are available for a few enteric pathogens including rotavirus and cholera, there are no vaccines licensed for many other enteric viral and bacterial pathogens. Challenges in enteric vaccine development include immunological heterogeneity among pathogen strains or isolates, a lack of animal challenge models to evaluate vaccine candidacy, undefined host immune correlates to protection, and a low protective efficacy among young children in endemic regions. In this article, we briefly updated the progress and challenges in vaccines and vaccine development for the leading enteric viral and bacterial pathogens including rotavirus, human calicivirus, Shigella, enterotoxigenic Escherichia coli (ETEC), cholera, nontyphoidal Salmonella, and Campylobacter, and introduced a novel epitope- and structure-based vaccinology platform known as MEFA (multiepitope fusion antigen) and the application of MEFA for developing broadly protective multivalent vaccines against heterogenous pathogens. |
| تدمد: | 1949-0984 1949-0976 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d16e464345cb2585adbe149523d9eefTest https://doi.org/10.1080/19490976.2020.1770666Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0d16e464345cb2585adbe149523d9eef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19490984 19490976 |
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