Putative adverse outcome pathways relevant to neurotoxicity
| العنوان: | Putative adverse outcome pathways relevant to neurotoxicity |
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| المؤلفون: | Andre Schrattenholz, Anna Forsby, Jochem Louisse, Magdalini Sachana, Maurice Whelan, Anna Bal-Price, Alan J. Hargreaves, Kevin M. Crofton, Ellen Fritsche, Brigitte Landesmann, Christoph van Thriel, Cristina Suñol, Alexandra Rolaki, Florianne Monnet-Tschudi, Alicia Paini, Mamta Behl, Timothy J. Shafer, Pamela J. Lein |
| المصدر: | Critical reviews in toxicology, vol 45, iss 1 Critical Reviews in Toxicology, 45(1), 83-91 Digital.CSIC. Repositorio Institucional del CSIC instname Bal-Price, A; Crofton, KM; Sachana, M; Shafer, TJ; Behl, M; Forsby, A; et al.(2015). Putative adverse outcome pathways relevant to neurotoxicity. Critical Reviews in Toxicology, 45(1), 83-91. doi: 10.3109/10408444.2014.981331. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6w88v9wvTest Critical Reviews in Toxicology 45 (2015) 1 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adverse outcomes, Alternatives to animal testing, predictive toxicology, Reference laboratory, Toxicology, Bioinformatics, Health outcomes, Risk Assessment, Article, Human health, Adverse outcome pathway, Predictive toxicology, Adverse Outcome Pathway, in vitro testing, Animals, Humans, Medicine, Toxicologie, health care economics and organizations, VLAG, Key events, business.industry, Neurotoxicity, key events, Pathways of neurotoxicity, Environmental Exposure, Pharmacology and Pharmaceutical Sciences, respiratory system, medicine.disease, Molecular initiating event, respiratory tract diseases, adverse outcome pathway, pathways of neurotoxicity, In vitro testing, Biological target, Neurotoxicity Syndromes, molecular initiating event, business |
| الوصف: | Anna K. Bal-Price et al. © 2015 Informa Healthcare USA. The Adverse Outcome Pathway (AOP) framework provides a template that facilitates understanding of complex biological systems and the pathways of toxicity that result in adverse outcomes (AOs). The AOP starts with an molecular initiating event (MIE) in which a chemical interacts with a biological target(s), followed by a sequential series of KEs, which are cellular, anatomical, and/or functional changes in biological processes, that ultimately result in an AO manifest in individual organisms and populations. It has been developed as a tool for a knowledge-based safety assessment that relies on understanding mechanisms of toxicity, rather than simply observing its adverse outcome. A large number of cellular and molecular processes are known to be crucial to proper development and function of the central (CNS) and peripheral nervous systems (PNS). However, there are relatively few examples of well-documented pathways that include causally linked MIEs and KEs that result in adverse outcomes in the CNS or PNS. As a first step in applying the AOP framework to adverse health outcomes associated with exposure to exogenous neurotoxic substances, the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) organized a workshop (March 2013, Ispra, Italy) to identify potential AOPs relevant to neurotoxic and developmental neurotoxic outcomes. Although the AOPs outlined during the workshop are not fully described, they could serve as a basis for further, more detailed AOP development and evaluation that could be useful to support human health risk assessment in a variety of ways. |
| وصف الملف: | application/pdf; application/octet-stream |
| تدمد: | 1547-6898 1040-8444 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888f8f5cc77de667c537ee3157ce18a0Test https://doi.org/10.3109/10408444.2014.981331Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....888f8f5cc77de667c537ee3157ce18a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15476898 10408444 |
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