SYMPATHETIC NERVOUS SYSTEM, DIABETES, AND HYPERTENSION
| العنوان: | SYMPATHETIC NERVOUS SYSTEM, DIABETES, AND HYPERTENSION |
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| المؤلفون: | P Cavallo Perin, R. Quadri, S. Maule |
| المصدر: | Clinical and Experimental Hypertension. 23:45-55 |
| بيانات النشر: | Informa UK Limited, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adrenergic Antagonists, medicine.medical_specialty, Sympathetic nervous system, Sympathetic Nervous System, Physiology, Nephropathy, Diabetes Complications, Insulin resistance, Diabetic Neuropathies, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Internal Medicine, medicine, Hyperinsulinemia, Humans, Diabetic Nephropathies, Type 1 diabetes, business.industry, General Medicine, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, medicine.anatomical_structure, Diabetes Mellitus, Type 2, Pathophysiology of hypertension, Hypertension, Insulin Resistance, Metabolic syndrome, business |
| الوصف: | Hypertension is twice as frequent in diabetic patients than in the general population. Its prevalence is higher in Type 2 than in Type 1 diabetes: in the former, the onset of hypertension often precedes the diagnosis of diabetes, whereas, in the latter it is strictly related to the presence of nephropathy. Sympathetic nerve overactivity is crucial in the pathogenesis of hypertension in diabetes. It can be related to the activation of the renin-angiotensin-aldosterone (RAA) system in Type 1 diabetic patients with chronic renal failure, or to a condition of insulin resistance/hyperinsulinemia in Type 2 patients with the metabolic syndrome. In patients with early autonomic neuropathy, vagal impairment can lead to a relative predominance of sympathetic activity in the sympatho-vagal balance. In these patients, the onset of hypertension is frequently preceded by reduced nocturnal dipping. Sympathetic overactivity stimulates RAA activity, promotes sodium reabsorption, and increases heart rate, stroke volume and peripheral vascular resistance, thus inducing hypertension and increasing cardiovascular risk. A number of drugs acting either directly or indirectly on sympathetic activity are available for the treatment of hypertension in diabetic subjects. Opinions on the potential advantages of the metabolic profile of some of these drugs are as yet conflicting. |
| تدمد: | 1525-6006 1064-1963 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9b3a5554ecc2e9a3163c4a6c0bed97Test https://doi.org/10.1081/ceh-100001196Test |
| رقم الانضمام: | edsair.doi.dedup.....4b9b3a5554ecc2e9a3163c4a6c0bed97 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15256006 10641963 |
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