Deletion of HOG1 Leads to Osmosensitivity in Starvation-Induced, but not Rapamycin-Dependent Atg8 Degradation and Proteolysis: Further Evidence for Different Regulatory Mechanisms in Yeast Autophagy
| العنوان: | Deletion of HOG1 Leads to Osmosensitivity in Starvation-Induced, but not Rapamycin-Dependent Atg8 Degradation and Proteolysis: Further Evidence for Different Regulatory Mechanisms in Yeast Autophagy |
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| المؤلفون: | Stephan vom Dahl, Tanja Prick, Michael Thumm, Dieter Häussinger |
| المصدر: | Autophagy. 2:241-243 |
| بيانات النشر: | Informa UK Limited, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Protein Denaturation, Saccharomyces cerevisiae Proteins, Osmotic shock, Proteolysis, ATG8, Biology, Models, Biological, Microtubule, Gene Expression Regulation, Fungal, Autophagy, medicine, Animals, Humans, Molecular Biology, Sirolimus, Starvation, medicine.diagnostic_test, Mechanism (biology), Autophagy-Related Protein 8 Family, Cell Biology, Water-Electrolyte Balance, Yeast, Cell biology, Biochemistry, Mitogen-Activated Protein Kinases, medicine.symptom, Microtubule-Associated Proteins, Gene Deletion |
| الوصف: | The mechanisms of regulation of autophagy are still obscure. In mammalian liver, starvation-induced autophagic proteolysis is regulated by the cellular hydration state in a microtubule- and p38MAPK-dependent way. Recent work shows that in yeast, loss of Hog1, the yeast orthologue of p38MAPK, leads to osmosensitivity of starvation-induced autophagy (Prick et al. Biochem J 2006; 394:153-61), pointing to an evolutionarily conserved mechanism. In this addendum further experiments from hog1delta yeast cells are shown, which support the hypothesis that starvation- and rapamycin-induced autophagy processes differ in their susceptibility to osmotic stress. The potential mechanisms are discussed. Addendum to:In Yeast, Loss of Hog1 Leads to Osmosensitivity of AutophagyT. Prick, M. Thumm, K. Kohrer, D. Haussinger and S. vom DahlBiochem J 2006; 394:153-61 |
| تدمد: | 1554-8635 1554-8627 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2764ea5d8522a9d897c7ef23793aa6cTest https://doi.org/10.4161/auto.2743Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b2764ea5d8522a9d897c7ef23793aa6c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15548635 15548627 |
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