دورية أكاديمية
The balancing act of autoimmunity: Central and peripheral tolerance versus infection control
| العنوان: | The balancing act of autoimmunity: Central and peripheral tolerance versus infection control |
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| المؤلفون: | Thomas, Ranjeny |
| المساهمون: | Roland Tisch |
| بيانات النشر: | Informa Healthcare |
| سنة النشر: | 2010 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Autoimmunity, Type 1 diabetes, Arthritis, Infection, 2403 Immunology, 2723 Immunology and Allergy |
| الوصف: | Genetic associations with autoimmune disease are enriched in immune response regulators. The immune system in individuals at genetic risk of autoimmunity must balance pressures on the innate and adaptive immune system, most notably infection control, with those of maintaining self-tolerance or controlling autoimmune inflammation. In spite of multiple tolerance mechanisms, inflammation becomes chronic in autoimmune disease, and complete resolution is difficult. This article proposes a perspective on the pathogenesis of autoimmunityfocusing on rheumatoid arthritis and type 1 diabetesintegrating clinical advances and animal models with the role that colonizing micro-organisms play in the balance between tolerance and autoimmunity. Copyright © 2010 Informa Healthcare USA, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0883-0185 1026-8006 1563-5244 |
| العلاقة: | orcid:0000-0002-0518-8386 |
| الإتاحة: | https://doi.org/10.3109/08830180903434219Test https://espace.library.uq.edu.au/view/UQ:211399Test |
| رقم الانضمام: | edsbas.2DAF7D6A |
| قاعدة البيانات: | BASE |
| تدمد: | 08830185 10268006 15635244 |
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