Use of salmeterol with and without concurrent use of inhaled corticosteroids and the risk of asthma-related hospitalization among patients with asthma
| العنوان: | Use of salmeterol with and without concurrent use of inhaled corticosteroids and the risk of asthma-related hospitalization among patients with asthma |
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| المؤلفون: | Cheng Liang Tsai, Robin B. Harris, Grant H. Skrepnek, Meng Ting Wang, Duane L. Sherrill, Daniel C. Malone, Edward P. Armstrong |
| المصدر: | Current Medical Research and Opinion. 24:859-867 |
| بيانات النشر: | Informa Healthcare, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, Severity of Illness Index, Pharmacotherapy, Adrenal Cortex Hormones, Risk Factors, immune system diseases, Internal medicine, Severity of illness, medicine, Humans, Albuterol, Salmeterol Xinafoate, Aged, Retrospective Studies, Asthma, Aged, 80 and over, business.industry, Case-control study, Retrospective cohort study, General Medicine, Adrenergic beta-Agonists, Middle Aged, medicine.disease, Bronchodilator Agents, respiratory tract diseases, Hospitalization, Treatment Outcome, Databases as Topic, Case-Control Studies, Anesthesia, Concomitant, Cohort, Drug Therapy, Combination, Female, Salmeterol, business, medicine.drug |
| الوصف: | Studies evaluating the safety of salmeterol are inconclusive, which might be the result from not taking into account the impact of concomitant inhaled corticosteroids (ICS).To study whether salmeterol use with and without concomitant ICS, respectively, was associated with an increased risk of asthma-related hospitalizations among patients with asthma.A case-control study nested within a cohort of patients with asthma, identified in the year 2000, over a 2-year period was conducted. Cases were subjects who had a first-time hospitalization for asthma in the year 2001, and were matched with up to five controls by age (+/- 5 years), sex, and number of asthma-related outpatient visits.Hospitalizations and medication use were extracted from the MEDSTAT's MarketScan database.There were 333 cases of asthma-related hospitalizations and 1607 matched control subjects. Any use of salmeterol with concomitant ICS use during the prior year was associated with a 32% risk reduction for being hospitalized due to asthma (OR = 0.68; 95% CI = 0.48, 0.96). In the presence of concomitant ICS use, patients who either used salmeterol currently or used seven or more canisters of salmeterol during the prior year had 46% (OR = 0.54, 95% CI = 0.32, 0.92), and 59% (OR = 0.41, 95% CI = 0.21, 0.79) reductions in the risk of hospital admissions for asthma, respectively.Though indirect measure of asthma severity was adjusted during the analyses, the lack of information on lung function might result in a selection bias. Additionally, only a small sample size of patients was found to use salmeterol without concomitant ICS use, and this introduced the issue of lack of power.Use of salmeterol in conjunction with ICS is associated with a decreased risk of hospital admission for asthma. |
| تدمد: | 1473-4877 0300-7995 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0274cde9c22b9346ae401521883ac2a1Test https://doi.org/10.1185/030079908x273020Test |
| رقم الانضمام: | edsair.doi.dedup.....0274cde9c22b9346ae401521883ac2a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14734877 03007995 |
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