Fulvestrant: a unique antiendocrine agent for estrogen-sensitive breast cancer
| العنوان: | Fulvestrant: a unique antiendocrine agent for estrogen-sensitive breast cancer |
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| المؤلفون: | Peter Kabos, Virginia F. Borges |
| المصدر: | Expert Opinion on Pharmacotherapy. 11:807-816 |
| بيانات النشر: | Informa Healthcare, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Antineoplastic Agents, Hormonal, medicine.drug_class, Estrogen receptor, Breast Neoplasms, Drug Delivery Systems, Breast cancer, Internal medicine, medicine, Animals, Humans, Pharmacology (medical), Neoplasm Metastasis, Aromatase, Fulvestrant, Pharmacology, Estradiol, biology, business.industry, Estrogen Antagonists, General Medicine, Antiestrogen, medicine.disease, Metastatic breast cancer, Estrogen, biology.protein, Neoplasm Recurrence, Local, business, Tamoxifen, medicine.drug |
| الوصف: | The role of estrogen deprivation for the treatment of breast cancer has been understood since the 1800s. Pharmacologic advances in the field in the past decades, including tamoxifen and the aromatase inhibitors, have contributed significantly to the reduced mortality of estrogen-sensitive breast cancer. However, this subtype of breast cancer still presents with relapses and, once metastatic, progression to hormone-refractory state and loss of disease control remain an expected disease course. Fulvestrant, a pure estrogen receptor downregulator, is a new addition to the antiestrogen therapeutic armamentarium since its FDA approval in 2002. Its unique mechanism of action offers potential advantages over other estrogen targeted therapies.Published scientific literature, including presented abstracts, on fulvestrant from 1985 to the present were reviewed with selected publications included.This review addresses current issues and therapies for estrogen-sensitive breast cancer, highlights the role of fulvestrant in current treatment guidelines and outlines some of the ongoing investigations of this compound.Fulvestrant is an effective and well-tolerated drug for treatment of metastatic estrogen-sensitive breast cancer. Work is underway to enhance its clinical benefit to patients as a single agent and in combination with other therapies. |
| تدمد: | 1744-7666 1465-6566 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1135587b93b47d445a70bfeeb6eaea12Test https://doi.org/10.1517/14656561003641982Test |
| رقم الانضمام: | edsair.doi.dedup.....1135587b93b47d445a70bfeeb6eaea12 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17447666 14656566 |
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