Pharmacokinetics of antiretrovirals in mucosal tissue
| العنوان: | Pharmacokinetics of antiretrovirals in mucosal tissue |
|---|---|
| المؤلفون: | Mackenzie L. Cottrell, Nithya Srinivas, Angela D. M. Kashuba |
| المصدر: | Expert Opinion on Drug Metabolism & Toxicology. 11:893-905 |
| بيانات النشر: | Informa Healthcare, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Drug, Anti-HIV Agents, media_common.quotation_subject, Biological Transport, Active, HIV Infections, Toxicology, Article, Pharmacokinetics, immune system diseases, medicine, Humans, Distribution (pharmacology), Tissue Distribution, HIV vaccine, media_common, Mucosal tissue, Pharmacology, Gastrointestinal tract, Mucous Membrane, business.industry, virus diseases, Mucous membrane, Genitalia, Female, General Medicine, Gastrointestinal Tract, medicine.anatomical_structure, Immunology, Female, business, Protein Binding, Hormone |
| الوصف: | In the absence of an HIV vaccine or cure, antiretroviral (ARV)-based prevention strategies are being investigated to reduce HIV incidence. These prevention strategies depend on achieving effective drug concentrations at the site of HIV exposure, which is most commonly the mucosal tissue of the lower gastrointestinal tract and the female genital tract.This article collates all known data regarding drug exposure in these vulnerable mucosal tissues and reviews important mechanisms of ARV drug distribution. Research papers and abstracts describing ARV pharmacokinetics (PK) in the female genital tract and lower gastrointestinal mucosal tissues available in MEDLINE® or presented at scientific conferences prior to December 2014 are reviewed in detail. Important influences on ARV mucosal tissue distribution, including protein binding, active drug transport and endogenous hormones are also reviewed.ARVs exhibit highly variable PK in mucosal tissues. In general, ARV exposure is higher in the lower gastrointestinal tract compared with the female genital tract, but concentrations required for protective efficacy are largely unknown. The expected site of HIV exposure represents an important consideration when designing and optimizing ARV-based prevention strategies. |
| تدمد: | 1744-7607 1742-5255 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3ae823d640f521fbbe8690a7de88e9Test https://doi.org/10.1517/17425255.2015.1027682Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe3ae823d640f521fbbe8690a7de88e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17447607 17425255 |
|---|