Safety of topotecan in the treatment of recurrent small-cell lung cancer and ovarian cancer
| العنوان: | Safety of topotecan in the treatment of recurrent small-cell lung cancer and ovarian cancer |
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| المؤلفون: | Jennifer Garst |
| المصدر: | Expert Opinion on Drug Safety. 6:53-62 |
| بيانات النشر: | Informa Healthcare, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Lung Neoplasms, endocrine system diseases, medicine.medical_treatment, Neutropenia, Internal medicine, medicine, Carcinoma, Humans, Pharmacology (medical), Carcinoma, Small Cell, Adverse effect, Lung cancer, Ovarian Neoplasms, Chemotherapy, business.industry, General Medicine, medicine.disease, Regimen, Female, Topotecan, Neoplasm Recurrence, Local, business, Ovarian cancer, medicine.drug |
| الوصف: | The topoisomerase I inhibitor, topotecan, is approved for the treatment of recurrent small-cell lung cancer (SCLC) and ovarian cancer (OC). Patients with recurrent SCLC and OC typically experience multiple relapses and receive multiple rounds of chemotherapy. In these settings, disease stabilisation is considered a treatment benefit, and quality-of-life effects and cumulative toxicities of treatments should be considered. Many patients with recurrent cancer may be predisposed to treatment-related adverse events because of advanced age, renal impairment or extensive prior therapy. The standard regimen of topotecan, 1.5 mg/m(2) on days 1-5 of a 21-day cycle, has generally mild nonhaematological toxicity and a well-defined haematological toxicity profile characterised by reversible and noncumulative neutropenia. Alternative regimens may lower the incidence of haematological toxicities and maintain antitumour efficacy. Topotecan may provide physicians with a versatile therapeutic option for the treatment of patients with relapsed SCLC or OC. |
| تدمد: | 1744-764X 1474-0338 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8078600843ab99af25adb2e44b12c8Test https://doi.org/10.1517/14740338.6.1.53Test |
| رقم الانضمام: | edsair.doi.dedup.....ff8078600843ab99af25adb2e44b12c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1744764X 14740338 |
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