دورية أكاديمية
The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer.
| العنوان: | The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer. |
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| المساهمون: | College of Medicine, Dept. of Pathology, Yoon Yang Jung, Yu Kyung Lee, Ja Seung Koo, Koo, Ja Seung, Lee, Yu Kyung |
| بيانات النشر: | Informa Healthcare England |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Animals, Antineoplastic Agents/pharmacology, Apoptosis Regulatory Proteins/genetics, Apoptosis Regulatory Proteins/metabolism, Autophagy/drug effects, Beclin-1, Breast Neoplasms/drug therapy, Breast Neoplasms/genetics, Breast Neoplasms/pathology, Disease Progression, Female, Gene Expression Regulation, Neoplastic, Humans, Membrane Proteins/genetics, Membrane Proteins/metabolism, Molecular Targeted Therapy, Neoplasm Staging, Beclin 1, autophagy, breast cancer, targeted drug therapy |
| الوصف: | INTRODUCTION: Beclin 1 plays a crucial role in autophagy via the Beclin 1 interactome, and is involved in various biological processes such as protein sorting, chemokinesis, and cell death. Via these biologic functions, Beclin 1 contributes to both tumor suppression and tumor progression. AREAS COVERED: Beclin 1 plays a key biologic function on cell homeostasis and affects tumorigenesis. In this review, detailing up-to-date knowledge on the tumorigenic role of Beclin 1, its implication in breast cancer, and its utility as a breast cancer-specific drug target is discussed. EXPERT OPINION: Because Beclin 1 is expressed in breast cancer cells, Beclin 1 could be a unique, effective drug target for the prevention and treatment of breast cancer. However, the expression of Beclin 1 varies according to cancer molecular subtypes, and Beclin 1 is involved in both breast cancer suppression and tumor progression; therefore, the decision of using a Beclin 1 inducer or inhibitor should be made based on breast cancer stage and subtype. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 167~178 |
| اللغة: | English |
| تدمد: | 1472-8222 1744-7631 |
| العلاقة: | EXPERT OPINION ON THERAPEUTIC TARGETS; J02865; OAK-2016-00560; https://ir.ymlib.yonsei.ac.kr/handle/22282913/146349Test; T201600269; EXPERT OPINION ON THERAPEUTIC TARGETS, Vol.20(2) : 167-178, 2016 |
| DOI: | 10.1517/14728222.2016.1085971 |
| الإتاحة: | https://doi.org/10.1517/14728222.2016.1085971Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/146349Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.378817CD |
| قاعدة البيانات: | BASE |
| تدمد: | 14728222 17447631 |
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| DOI: | 10.1517/14728222.2016.1085971 |