Recent developments in 5lipoxygenase inhibitors
العنوان: | Recent developments in 5lipoxygenase inhibitors |
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المؤلفون: | F. Julemont, Didier Laeckmann, X. De Leval, Bernard Pirotte, Jean-Michel Dogné |
المصدر: | Expert Opinion on Therapeutic Patents. 13:1-13 |
بيانات النشر: | Informa Healthcare, 2003. |
سنة النشر: | 2003 |
مصطلحات موضوعية: | Pharmacology, chemistry.chemical_classification, biology, Leukotriene Production, Cancer, Inflammation, General Medicine, medicine.disease, chemistry.chemical_compound, Lipoxygenase, Enzyme, Biochemistry, chemistry, Arachidonate 5-lipoxygenase, Drug Discovery, Second messenger system, medicine, biology.protein, Arachidonic acid, medicine.symptom |
الوصف: | Arachidonic acid (AA) can be metabolised by various enzymes, most notably the cyclooxygenases and the lipoxygenases. The secondary messenger pathway leads to the formation of mediators that are implicated in pathologies such as asthma, inflammation and cancer. Leukotrienes (LTs) are produced through the lipoxygenase pathway. The observation that modulation of leukotriene production by inhibition of 5-lipoxygenase (5-LOX) leads to therapeutic benefit has encouraged research of potent 5-LOX inhibitors. As a consequence, many patents concerning 5-LOX inhibition and the uses of 5LOX inhibitors as therapeutic agents are claimed each year. This article reviews these patents for the period 1999 – 2002. |
تدمد: | 1744-7674 1354-3776 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5b7f3a0d2ee4971d0db7afe36e7e65Test https://doi.org/10.1517/13543776.13.1.1Test |
رقم الانضمام: | edsair.doi.dedup.....4a5b7f3a0d2ee4971d0db7afe36e7e65 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 17447674 13543776 |
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