Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)
| العنوان: | Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) |
|---|---|
| المؤلفون: | John Littell, Alexandre Giandoni Wolkoff, Karladine E. Graves, Russell S. Gonnering, Stella Immanuel, John E. McKinnon, Sabine Hazan, Lee D. Merritt, Brian C. Procter, Richard A. Eisner, Robin L. Armstrong, Donald C. Pompan, Martin Scholz, Michael J. A. Robb, Kelly Victory, Vladimir Zelenko, Peter A. McCullough, Salete da Silva Rios, Richard P. Bartlett, Craig M. Wax, Paul E. Alexander, Vicki Wooll, Robert Berkowitz, Charles E. Geyer, Kristin S. Held, George Fareed, Juliana Cepelowicz Rajter, Harvey A. Risch, Molly Rutherford, Richard G. Urso, Roland Derwand, Adam Brufsky, Teryn Clarke, Lionel H. Lee, Chad Prodromos, Ivette Lozano, Ben Marble, Harpal S. Mangat, Thomas J. Borody, Jane M. Orient, Silvia Nunes Szente Fonseca, John Eck, Joseph H. Brewer, Brian M. Tyson, Angelina Farella, Ramin Oskoui, Joseph A. Ladapo, Marilyn M. Singleton, Andrew C. Berry, Alan F. Bain, Cristian Arvinte, Michael M. Jacobs, Kenneth B. V. Gross, Elizabeth Lee Vliet, Jean-Jacques Rajter, James A. Tumlin, Alieta Eck, H. Thomas Hight, C. Venkata S. Ram |
| المصدر: | Reviews in Cardiovascular Medicine, Vol 21, Iss 4, Pp 517-530 (2020) Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB |
| بيانات النشر: | IMR Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Drug, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, corticosteroid, Tratamento, medicine.drug_class, media_common.quotation_subject, Leprostatic Agents, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, Therapeutic approach, 0302 clinical medicine, Pharmacotherapy, Randomized controlled trial, law, Epidemiology, Pandemic, Medicine, Humans, ambulatory treatment, Intensive care medicine, Pandemics, media_common, anti-inflammatory, Hospitalização, business.industry, SARS-CoV-2, Anticoagulant, anticoagulant, sequenced multidrug therapy, COVID-19, General Medicine, medicine.disease, antiplatelet agent, antiviral, mortality, Telemedicine, COVID-19 Drug Treatment, anti-infective, lcsh:RC666-701, Mortalidade, Medicamentos, Drug Therapy, Combination, Cardiology and Cardiovascular Medicine, business, Cytokine storm, Covid-19, hospitalization |
| الوصف: | The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine. Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3d15452c8df06e4dcda7102fe62c82Test http://hdl.handle.net/11375/26557Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fa3d15452c8df06e4dcda7102fe62c82 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |