التفاصيل البيبلوغرافية
| العنوان: |
Lipocalin 2: could it be a new biomarker in pediatric pulmonary hypertension associated with congenital heart disease? |
| المؤلفون: |
Hongju Zhang, Tao Sun, Jiao Yang, Yan Sun, Guowen Liu, Krittanawong, Chayakrit, El-Am, Edward A., Bou Chaaya, Rody G., Liyuan Xu, Zankai Ye, Zhiqiang Li, Ning Ma, Zhang, Hongju, Sun, Tao, Yang, Jiao, Sun, Yan, Liu, Guowen, Chaaya, Rody G Bou, Xu, Liyuan, Ye, Zankai |
| المصدر: |
Reviews in Cardiovascular Medicine; Jun2021, Vol. 22 Issue 2, p531-536, 6p |
| مستخلص: |
The role of lipocalin 2 (LCN2) in pulmonary hypertension (PH) in pediatric patients with congenital heart disease (CHD) remains unclear. We sought to investigate whether LCN2 could be a potential biomarker for PH in pediatric patients who underwent surgery for CHD. From December 2018 to February 2020, patients undergoing surgical repair for congenital defects with and without PH were identified. Healthy children without CHD and PH served as controls. A mean pulmonary artery pressure (mPAP) >20 mmHg was used as the definition of PH. Blood samples and echocardiograms were obtained in all patients and right heart catheterization was performed in 79 patients. Multivariable logistic regression analysis was used to determine potential predictors for PH. Among 102 patients, the median age was 10 [Interquartile range (IQR) 7.0-13] months, and 37.5% were female. Compared to non-PH patients and controls, PH patients showed elevated levels of LCN2 (P < 0.001). In addition, LCN2 levels positively correlated with the invasive haemodynamic indices of PH. In univariate regression, LCN2 (odds ratio = 2.69 [1.06-5.31], P < 0.001), N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) (OR = 1.91 [1.21-7.56], P = 0.03) and high-sensitive troponin T (hsTnT) (OR = 1.36 [1.01-3.57], P = 0.01) were associated with PH; however, only LCN2 (OR = 1.68 [1.04-4.52], P = 0.03) was significantly associated with PH on multivariate analysis. In conclusion, children with PH had increased LCN2 expression. LCN2 levels positively correlated with invasive indices of PH. These results indicate LCN2 could be a useful biomarker for prediction of PH in pediatric CHD cases. [ABSTRACT FROM AUTHOR] |
|
Copyright of Reviews in Cardiovascular Medicine is the property of IMR Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
