Orphan nuclear receptor function in the ovary
| العنوان: | Orphan nuclear receptor function in the ovary |
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| المؤلفون: | Austin J. Cooney, Zili Li, Zi-Jian Lan, Huajun Zhao |
| المصدر: | Frontiers in Bioscience. 12:3398 |
| بيانات النشر: | IMR Press, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Orphan receptor, Steroidogenic factor 1, endocrine system, medicine.medical_specialty, Germ cell nuclear factor, Liver receptor homolog-1, Ovary, Nuclear Proteins, Biology, medicine.disease, Premature ovarian failure, Cell biology, Mice, medicine.anatomical_structure, Endocrinology, Nuclear receptor, Internal medicine, medicine, Animals, Humans, Female, Ovarian Diseases, Ovarian cancer |
| الوصف: | Orphan nuclear receptors such as germ cell nuclear factor (GCNF), steroidogenic factor 1 (SF-1) and liver receptor homolog-1 (LRH-1), are emerging as important ovarian factors in regulating female reproduction. Within the ovary, GCNF (NR6A1) expression is restricted to the oocyte, while SF-1 (NR5A1) is expressed only in the somatic cells, such as granulosa, thecal and luteal cells, and interstitial cells. LRH-1 (NR5A2), an orphan receptor closely related to SF-1, is expressed only in the granulosa cells of the follicles and luteal cells within the ovary. Recent studies using conditional knockout strategies to bypass the embryonic lethality of GCNF and SF-1 null mice have uncovered important roles of GCNF and SF-1 in the oocyte and granulosa cells, respectively. In this review, we will summarize the major findings of GCNF and SF-1 in the ovary from the studies of conditional GCNF and SF-1 knockout mice. The potential role of LRH-1 in the ovary is also briefly discussed. Understanding the ovarian functions of these orphan nuclear receptors may lead to the development of new agents for regulation of female fertility and new medicines for the treatment of female idiopathic infertility, premature ovarian failure, polycystic ovarian syndrome and ovarian cancer. |
| تدمد: | 1093-4715 1093-9946 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a50c0ab946eed5857e208331969cfaTest https://doi.org/10.2741/2321Test |
| رقم الانضمام: | edsair.doi.dedup.....24a50c0ab946eed5857e208331969cfa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10934715 10939946 |
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