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// Xiaohong Wang 1, 2, * , Chenguang Dai 3, * , Zhonghua Jiang 1, 4 , Lili Zhao 3 , Min Wang 3 , Limei Ma 3 , Xueming Tan 3 , Li Liu 3 , Xiang Wang 3 and Zhining Fan 3 1 Department of Digestive Endoscopy and Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China 2 Department of Gastroenterology, The Second Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221006, China 3 Digestive Endoscopy Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, China 4 Department of Gastroenterology, The First People’s Hospital of Yancheng, Yancheng, Jiangsu 224006, China * These authors have contributed equally to this work Correspondence to: Zhining Fan, email: fanzhining@njmu.edu.cn Keywords: ERCP (endoscopic retrograde cholangiopancreatography), LCBDE (laparoscopic common bile duct exploration), common bile duct, post-cholecystectomy, retrospective study Received: November 22, 2016 Accepted: March 22, 2017 Published: June 27, 2017 ABSTRACT Background and Objective: Common bile duct (CBD) stones are common in patients even after cholecystectomy. Besides endoscopic retrograde cholangiography (ERCP), laparoscopic common bile duct exploration (LCBDE) is also applied. This study aims to compare clinical indications, therapeutic benefits and complications for these two managements. Methods: From October 2012 to February 2015, 1072 consecutive patients were diagnosed as choledocholithiasis in our single hospital. Post-cholecystectomy patients who underwent ERCP or LCBDE were included. Clinical data were analyzed, such as success rate, complications, procedure duration, postoperative hospital stay, total cost and recurrence of ductal stones. Prior ERCP, previous biliary anatomic alteration surgeries and lost to follow up were the excluding criteria. Results: 141 patients were included according to the criteria, and 87 cases underwent ERCP and 54 cases underwent LCBDE. Age and sex distribution of patients were comparable between the two groups. The success rate for CBD stones clearance was 97.7% in the ERCP group, compared with 87.0% in the LCBDE group ( p =0.03). The mean procedure duration was also significantly shorter in ERCP group (52.0±15.8 vs. 102.9±40.1 min; p |