AXL is an oncotarget in human colorectal cancer
| العنوان: | AXL is an oncotarget in human colorectal cancer |
|---|---|
| المؤلفون: | Rosa Marina Melillo, Vincenzo Rosario Iaffaioli, Anna Nappi, Teresa Troiani, Gerardo Botti, Giuseppina Liguori, Floriana Morgillo, Claudia Cardone, Fortunato Ciardiello, Liberato Berrino, Federica Liotti, Stefania Napolitano, Davide Ciardiello, Giulia Martini, Fiorella Angelica Valeria Ferraiolo, Barbara Rinaldi, Loreta Pia Ciuffreda, Roberto Bianco, Donata Vitagliano, Erika Martinelli |
| المساهمون: | Martinelli, Erika, Martini, G, Cardone, C, Troiani, Teresa, Liguori, G, Vitagliano, D, Napolitano, S, Morgillo, Floriana, Rinaldi, Barbara, Melillo, Rm, Liotti, F, Nappi, A, Bianco, R, Berrino, Liberato, Ciuffreda, Lp, Ciardiello, D, Iaffaioli, V, Botti, G, Ferraiolo, F, Ciardiello, F., Martini, Giulia, Cardone, Claudia, Liguori, Giuseppina, Vitagliano, Donata, Napolitano, Stefania, Melillo, ROSA MARINA, Liotti, Federica, Nappi, Anna, Bianco, Roberto, Ciuffreda, Loreta Pia, Ciardiello, Davide, Iaffaioli, Vincenzo, Botti, Gerardo, Ferraiolo, Fiorella, Ciardiello, Fortunato |
| المصدر: | Oncotarget Europe PubMed Central Oncotarget 6 (2015): 23281–23296. doi:10.18632/oncotarget.3962 info:cnr-pdr/source/autori:Martinelli, Erika; Martini, Giulia; Cardone, Claudia; Troiani, Teresa; Liguori, Giuseppina; Vitagliano, Donata; Napolitano, Stefania; Morgillo, Floriana; Rinaldi, Barbara; Melillo, Rosa Marina; Liotti, Federica; Nappi, Anna; Bianco, Roberto; Berrino, Liberato; Ciuffreda, Loreta Pia; Ciardiello, Davide; Iaffaioli, Vincenzo; Botti, Gerardo; Ferraiolo, Fiorella; Ciardiello, Fortunato/titolo:AXL is an oncotarget in human colorectal cancer/doi:10.18632%2Foncotarget.3962/rivista:Oncotarget/anno:2015/pagina_da:23281/pagina_a:23296/intervallo_pagine:23281–23296/volume:6 |
| بيانات النشر: | Impact Journals LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Colorectal cancer, Angiogenesis, Receptor tyrosine kinase, chemistry.chemical_compound, Mice, Cell Movement, GAS6, Anilides, In Situ Hybridization, Fluorescence, Oligonucleotide Array Sequence Analysis, Aged, 80 and over, Mice, Inbred BALB C, Neovascularization, Pathologic, Middle Aged, Immunohistochemistry, Oncology, Quinolines, Intercellular Signaling Peptides and Proteins, Female, RNA Interference, Colorectal Neoplasms, Adult, foretinib, Cell Survival, Mice, Nude, colorectal cancer, Antineoplastic Agents, Biology, FISH, Cell Line, Tumor, Proto-Oncogene Proteins, Pathology Section, medicine, Gene silencing, Animals, Humans, Gene Silencing, neoplasms, Aged, Cell Proliferation, Cell growth, Foretinib, AXL, Receptor Protein-Tyrosine Kinases, medicine.disease, HCT116 Cells, Axl Receptor Tyrosine Kinase, digestive system diseases, Research Paper: Pathology, chemistry, Cancer research, biology.protein, Neoplasm Transplantation |
| الوصف: | AXL is a tyrosine kinase receptor activated by GAS6 and regulates cancer cell proliferation migration and angiogenesis. We studied AXL as new therapeutic target in colorectal cancer (CRC). Expression and activation of AXL and GAS6 were evaluated in a panel of human CRC cell lines. AXL gene silencing or pharmacologic inhibition with foretinib suppressed proliferation, migration and survival in CRC cells. In an orthotopic colon model of human HCT116 CRC cells overexpressing AXL, foretinib treatment caused significant inhibition of tumour growth and peritoneal metastatic spreading. AXL and GAS6 overexpression by immunohistochemistry (IHC) were found in 76,7% and 73.5%, respectively, of 223 human CRC specimens, correlating with less differentiated histological grading. GAS6 overexpression was associated with nodes involvement and tumour stage. AXL gene was found amplified by Fluorescence in situ hybridization (FISH) in 8/146 cases (5,4%) of CRC samples. Taken together, AXL inhibition could represent a novel therapeutic approach in CRC. |
| اللغة: | English |
| تدمد: | 1949-2553 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c3a58af6c1e8909557c8cca4cb94a0Test http://europepmc.org/articles/PMC4695118Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26c3a58af6c1e8909557c8cca4cb94a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19492553 |
|---|