Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
| العنوان: | Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors |
|---|---|
| المؤلفون: | Antonio M. Lerario, Céline Pinheiro, Sara Granja, Maria Candida Barisson Villares Fragoso, Mariateresa C. N. Zerbini, André M. Faria, Fátima Baltazar, Silvana Maria Lovisolo, Adhemar Longatto-Filho, Madson Q. Almeida |
| المساهمون: | Universidade do Minho |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Oncotarget ResearcherID |
| بيانات النشر: | Impact Journals LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Pathology, Time Factors, adrenocortical tumors, Muscle Proteins, Adrenocortical tumors, Kaplan-Meier Estimate, Metastasis, Adrenocortical adenoma, Adrenocortical Carcinoma, Adrenocortical carcinoma, metabolic reprogramming, Carbonic Anhydrases, Aged, 80 and over, Glucose Transporter Type 1, Symporters, Metabolic reprogramming, Middle Aged, monocarboxylate transporter, Immunohistochemistry, Hyaluronan Receptors, Treatment Outcome, Oncology, Adrenocortical Adenoma, Female, Research Paper, Adult, Monocarboxylic Acid Transporters, Prognostic variable, medicine.medical_specialty, Mitotic index, Adolescent, Biology, Disease-Free Survival, Young Adult, Antigens, Neoplasm, medicine, Biomarkers, Tumor, Mitotic Index, Humans, Carbonic Anhydrase IX, Aged, Neoplasm Staging, Proportional Hazards Models, Science & Technology, Proportional hazards model, Monocarboxylate transporter, CD44, medicine.disease, Adrenal Cortex Neoplasms, biology.protein, Cancer research, Basigin, Warburg effect, Neoplasm Grading, Energy Metabolism |
| الوصف: | Adrenocortical carcinomas (ACCs) are complex neoplasias that may present unexpected clinical behavior, being imperative to identify new biological markers that can predict patient prognosis and provide new therapeutic options. The main aim of the present study was to evaluate the prognostic value of metabolism-related key proteins in adrenocortical carcinoma. The immunohistochemical expression of MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX was evaluated in a series of 154 adult patients with adrenocortical neoplasia and associated with patients’ clinicopathological parameters. A significant increase in was found for membranous expression of MCT4, GLUT1 and CAIX in carcinomas, when compared to adenomas. Importantly MCT1, GLUT1 and CAIX expressions were significantly associated with poor prognostic variables, including high nuclear grade, high mitotic index, advanced tumor staging, presence of metastasis, as well as shorter overall and disease free survival. In opposition, MCT2 membranous expression was associated with favorable prognostic parameters. Importantly, cytoplasmic expression of CD147 was identified as an independent predictor of longer overall survival and cytoplasmic expression of CAIX as an independent predictor of longer disease-free survival. We provide evidence for a metabolic reprogramming in adrenocortical malignant tumors towards the hyperglycolytic and acid-resistant phenotype, which was associated with poor prognosis. This work was supported by FAPESP to Maria Claudia Nogueira Zerbini (2013-26344-8). SG received the post-doctoral fellowship UMINHO/BPD/18/2014. info:eu-repo/semantics/publishedVersion |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7600bee5e6a5d3498ae96991c7859c8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f7600bee5e6a5d3498ae96991c7859c8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |