CK1δ as a potential therapeutic target to treat bladder cancer

التفاصيل البيبلوغرافية
العنوان: CK1δ as a potential therapeutic target to treat bladder cancer
المؤلفون: Chun Han Chen, Yu Chen Lin, Jing Ping Liou, Mei Chuan Chen, Tsung Han Hsieh
المصدر: Aging (Albany NY)
بيانات النشر: Impact Journals, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Aging, Necroptosis, necroptosis, Malignancy, urologic and male genital diseases, migration, Erdafitinib, Cell Movement, Cell Line, Tumor, medicine, Humans, Cell Proliferation, Gene knockdown, Bladder cancer, business.industry, CK1δ, Mesenchymal stem cell, Cell Cycle, apoptosis, Cancer, Cell Biology, medicine.disease, Up-Regulation, Gene Expression Regulation, Neoplastic, Pyrimidines, Urinary Bladder Neoplasms, Apoptosis, Casein Kinase Idelta, Gene Knockdown Techniques, Cancer research, bladder cancer, business, Research Paper
الوصف: Bladder cancer is the second most common genitourinary malignancy in the world. However, only immune-checkpoint inhibitors and erdafitinib are available to treat advanced bladder cancer. Our previous study reported that 4-((4-(4-ethylpiperazin-1-yl) phenyl)amino)-N-(3,4,5-trichlorophenyl)-7H-pyrrolo-[2, 3-d]pyrimidine-7-carboxamide hydrochloride (13i HCl) is a potent CK1δ inhibitor showing significant anti-bladder cancer activity. In this study, we elucidated the pharmacological mechanisms underlying 13i HCl's inhibition of human bladder cancer. Our results demonstrate that expression of the CSNK1D gene, which codes for CK1δ, is upregulated in superficial and infiltrating bladder cancer patients in two independent datasets. CK1δ knockdown decreased β-catenin expression in bladder cancer cells and inhibited their growth. Additionally, 13i HCl suppressed bladder cancer cell proliferation and increased apoptosis. We also observed that inhibition of CK1δ using 13i HCl or PF-670462 triggers necroptosis in bladder cancer cells. Finally, 13i HCl inhibited bladder cancer cell migration and reversed their mesenchymal characteristics. These findings suggest further development of 13i HCl as a potential therapeutic agent to treat bladder cancer is warranted.
اللغة: English
تدمد: 1945-4589
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849e261a0f006640e6acdecf78aa8b4aTest
http://europepmc.org/articles/PMC7185098Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....849e261a0f006640e6acdecf78aa8b4a
قاعدة البيانات: OpenAIRE