دورية أكاديمية
Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke
| العنوان: | Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke |
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| المساهمون: | College of Medicine, Dept. of Physiology, Jongman Yoo, Han-Soo Kim, Jin-Ju Seo, Jang-Hyoun Eom, Seong-Mi Choi, Sanghyun Park, Dong-Wook Kim, Dong-Youn Hwang, Kim, Dong Wook |
| بيانات النشر: | Impact Journals United States |
| سنة النشر: | 2016 |
| الوصف: | Umbilical cord blood plasma (UCB-PL) contains various cytokines, growth factors, and immune modulatory factors that regulate the proliferation and function of immune cells and adult stem cells. Despite its therapeutic potential, the effects of UCB-PL treatment in conditions of ischemic brain injury have yet to be investigated. In this study, we demonstrated that both behavioral and structural impairments resulting from ischemic brain injury were significantly prevented/reversed after intravenous administration of UCB-PL relative to the vehicle control. As early as 1-week post-ischemia, an increased number of newborn cells in the subventricular zone and a reduced number of activated microglial cells in the peri-infarct area were observed in the UCB-PL group, suggesting that enhanced neurogenesis and/or the suppression of inflammation may have contributed to functional protection/recovery. Moreover, UCB-PL was more effective than plasma derived from a 65-year-old healthy adult for the treatment of ischemia-related structural and functional deficits, indicating that UCB-PL had greater therapeutic potential. This study provides valuable insights into the development of a safe, effective, and cell-free strategy for the treatment of ischemic brain damage and a much-needed alternative for patients who are ineligible for thrombolytic therapy. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1949-2553 |
| العلاقة: | ONCOTARGET; J02421; OAK-2016-08156; https://ir.ymlib.yonsei.ac.kr/handle/22282913/152888Test; T201605613; ONCOTARGET , Vol.7(48) : 79131-79140, 2016; 40512 |
| DOI: | 10.18632/oncotarget.12998 |
| الإتاحة: | https://doi.org/10.18632/oncotarget.12998Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/152888Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.526D3951 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19492553 |
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| DOI: | 10.18632/oncotarget.12998 |