دورية أكاديمية
Meta-analysis on the association of VEGFR1 genetic variants with sunitinib outcome in metastatic renal cell carcinoma patients
| العنوان: | Meta-analysis on the association of VEGFR1 genetic variants with sunitinib outcome in metastatic renal cell carcinoma patients |
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| المؤلفون: | Liu, Xiaoyan, Swen, Jesse J, Boven, Epie, Castellano, Daniel, Gelderblom, Hans, Mathijssen, Ron H J, Rodriguez Antona, Cristina, García-Donas, Jesus, Rini, Brian I, Guchelaar, Henk-Jan |
| المساهمون: | Pfizer, China Scholarship Council |
| بيانات النشر: | Impact Journals |
| سنة النشر: | 2017 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | VEGFR1, Meta-analysis, Metastatic renal cell carcinoma, Sunitinib, Validation study, Alleles, Antineoplastic Agents, Carcinoma, Renal Cell, Gene Frequency, Genotype, Humans, Indoles, Kidney Neoplasms, Neoplasm Metastasis, Polymorphism, Single Nucleotide, Prognosis, Proportional Hazards Models, Pyrroles, Treatment Outcome, Vascular Endothelial Growth Factor Receptor-1, Genetic Variation |
| الوصف: | VEGFR1 rs9582036 and rs9554320 were previously reported the association with sunitinib progression-free survival (PFS) and overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC). Hereafter, the association of both single nucleotide polymorphisms (SNPs) with PFS/OS was confirmed in two independent mRCC cohorts. The aim of the current study was to validate the associations of both SNPs with sunitinib outcome in three independent well-characterized cohorts (SUTOX, CCF and SOGUG) including 286 sunitinib-treated mRCC patients, as well as to perform a meta-analysis of current and published data combined. We found that rs9582036 and rs9554320 showed a significant association with sunitinib PFS in the CCF cohort (HR: 0.254, 95%CI: 0.092-0.703; P=0.008 and HR: 0.430, 95%CI: 0.200-0.927; P=0.031, respectively). Patients with the variant genotype of rs9582036 and rs9554320 had a shorter median PFS. No significant association of both SNPs with sunitinib PFS or OS was detected in either the SUTOX or SOGUG cohort. After the combination of all available data into a meta-analysis, the association of both SNPs with sunitinib PFS or OS did not achieve the threshold for statistical significance. Our findings suggest that, although VEGFR1 rs9582036 and rs9554320 are involved in sunitinib therapy outcome, its clinical use as biomarkers for prediction of sunitinib outcome in mRCC patients is limited, due to inconsistent findings when analyzing all existing studies together. ; Pfizer supports this research by an unrestricted research grant. Xiaoyan Liu is supported by the Chinese Scholarship Council (No. 201406220186). ; Sí |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1949-2553 27901483 |
| العلاقة: | Publisher's version; https://doi.org/10.18632/oncotarget.13597Test.; Oncotarget. 2017 ;8(1):1204-1212; http://hdl.handle.net/20.500.12105/8486Test; Oncotarget |
| DOI: | 10.18632/oncotarget.13597 |
| الإتاحة: | https://doi.org/20.500.12105/8486Test https://doi.org/10.18632/oncotarget.13597Test https://hdl.handle.net/20.500.12105/8486Test |
| حقوق: | http://creativecommons.org/licenses/by-nc-sa/4.0Test/ ; Atribución-NoComercial-CompartirIgual 4.0 Internacional ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.734942BA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19492553 27901483 |
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| DOI: | 10.18632/oncotarget.13597 |