التفاصيل البيبلوغرافية
العنوان:
Molecular Insights into Therapeutic Potentials of Hybrid Compounds Targeting Alzheimer’s Disease
المؤلفون:
Ankit Jana , Arkadyuti Bhattacharjee , Sabya Sachi Das , Avani Srivastava , Akshpita Choudhury , Rahul Bhattacharjee , Swagata De , Asma Perveen , Danish Iqbal , Piyush Kumar Gupta , Saurabh Kumar Jha , Shreesh Ojha , Sandeep Kumar Singh , Janne Ruokolainen , Niraj Kumar Jha , Kavindra Kumar Kesari , Ghulam Md Ashraf
المساهمون:
Kalinga Institute of Industrial Technology, Birla Institute of Technology, Mesra, University of Burdwan, Glocal University, Majmaah University, Sharda University, United Arab Emirates University, Department of Applied Physics, King Abdulaziz University, Aalto-yliopisto, Aalto University
بيانات النشر:
Humana Press, 2022.
سنة النشر:
2022
مصطلحات موضوعية:
Cellular and Molecular Neuroscience , Neuronal molecular targets , Neurology , Cellular pathways , Targeted hybrid therapeutics , Neuroscience (miscellaneous) , Pathogenesis , Alzheimer’s disease
الوصف:
Funding Information: Dr. Niraj Kumar Jha is thankful to Sharda University for the infrastructure and facility. The author would like to thank Deanship of Scientific Research at Majmaah University for supporting this work under project number No. R-2022-68. Kavindra Kumar Kesari and Janne Ruokolainen thanking Aalto University for providing open access support. The authors would like to acknowledge the support from their respective institutes throughout the review writing process. Publisher Copyright: © 2022, The Author(s). Alzheimer’s disease (AD) is one of the most complex progressive neurological disorders involving degeneration of neuronal connections in brain cells leading to cell death. AD is predominantly detected among elder people (> 65 years), mostly diagnosed with the symptoms of memory loss and cognitive dysfunctions. The multifarious pathogenesis of AD comprises the accumulation of pathogenic proteins, decreased neurotransmission, oxidative stress, and neuroinflammation. The conventional therapeutic approaches are limited to symptomatic benefits and are ineffective against disease progression. In recent years, researchers have shown immense interest in the designing and fabrication of various novel therapeutics comprised of naturally isolated hybrid molecules. Hybrid therapeutic compounds are developed from the combination of pharmacophores isolated from bioactive moieties which specifically target and block various AD-associated pathogenic pathways. The method of designing hybrid molecules has numerous advantages over conventional multitarget drug development methods. In comparison to in silico high throughput screening, hybrid molecules generate quicker results and are also less expensive than fragment-based drug development. Designing hybrid-multitargeted therapeutic compounds is thus a prospective approach in developing an effective treatment for AD. Nevertheless, several issues must be addressed, and additional researches should be conducted to develop hybrid therapeutic compounds for clinical usage while keeping other off-target adverse effects in mind. In this review, we have summarized the recent progress on synthesis of hybrid compounds, their molecular mechanism, and therapeutic potential in AD. Using synoptic tables, figures, and schemes, the review presents therapeutic promise and potential for the development of many disease-modifying hybrids into next-generation medicines for AD.
وصف الملف:
application/pdf
اللغة:
English
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f772ecdcb3f955d700a7447f3941b35bTest https://aaltodoc.aalto.fi/handle/123456789/114793Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....f772ecdcb3f955d700a7447f3941b35b
قاعدة البيانات:
OpenAIRE
