Comparison of Proliferative Activity in Coronary Plaques from Patients with Coronary Ischemia
| العنوان: | Comparison of Proliferative Activity in Coronary Plaques from Patients with Coronary Ischemia |
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| المؤلفون: | Ueda, Hironori, Imazu, Michinori, Hayashi, Yasuhiko, Ono, Koichi, Yasui, Wataru, Yamakido, Michio |
| المصدر: | Hiroshima Journal of Medical Sciences. 46(1):31-42 |
| بيانات النشر: | Hiroshima University Medical Press, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Restenosis, Proliferating cell nuclear antigen (PCNA), Acute coronary syndromes, Directional coronary atherectomy (DCA) |
| الوصف: | The overgrowth of cells of the vessel wall, especially of the smooth muscle cells (SMCs), contributes to the pathogenesis of coronary atherosclerosis and wound repair after coronary angioplasty. However, the association between cellular proliferation in coronary lesions and clinical pathophysiology remains to be clarified in humans. Thus, we investigated proliferative activity in coronary tissues obtained from patients with coronary ischemia. The proliferative activity in tissues obtained by using directional coronary atherectomy (DCA) from 87 coronary lesions was assessed by immunohistochemical staining for the proliferating cell nuclear antigen (PCNA). The lesions were divided into 34 primary lesions and 53 postangioplasty lesions. The 34 primary tissue samples were obtained from 9 patients with stable angina pectoris (SAP) and 25 patients with acute coronary syndromes (ACS). Collectively, the 53 postangioplasty tissue samples were obtained from 37 patients with SAP and 16 patients with ACS. The PCNA labeling index (LI) was quantified as the mean percentage of PCNA-positive cells in the 3 most positive high-power fields (×200). The mean Lis were high in the primary ACS samples [8.9 ± 2.1 % (p=0.01)] and postangioplasty samples [2.3 ± 0.8% (p=0.08) in SAP cases and 4.1 ± 2.4% (p=0.06) in ACS cases] compared with the primary SAP samples (0.2 ± 0.2%). Intimal hyperplasia, a random proliferation of SMCs (a-actin positive) was marked in the primary ACS samples (76%) as well as in the postangioplasty SAP (92%) and ACS (81 %) samples, as compared with the primary SAP samples (33%) (p This work was supported in part by grants from the Tsuchiya foundation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0018-2052 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::420829172d77c0bd5dd0b5811d643e5bTest http://ir.lib.hiroshima-u.ac.jp/00037815Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..420829172d77c0bd5dd0b5811d643e5b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00182052 |
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