دورية أكاديمية
Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer
العنوان: | Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer |
---|---|
المؤلفون: | Liu‐Jing Wen, Yue‐Sheng Wang, Jie Zhang |
المصدر: | IET Nanobiotechnology, Vol 17, Iss 2, Pp 49-60 (2023) |
بيانات النشر: | Hindawi-IET, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Biotechnology |
مصطلحات موضوعية: | breast cancer, doxorubicin, drug loaded hybrid micelles, elacridar, gold nanoparticles, Biotechnology, TP248.13-248.65 |
الوصف: | Abstract The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug‐resistant in breast cancer cells. Nano‐gold micelles loaded with Dox and Elacridar (FP‐ssD@A‐E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP‐ssD@A‐E gradually increased, and the drug loading rate gradually decreased. FP‐ss@A‐E had a sustained‐release effect. Dox, Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E significantly improved cell apoptosis, in which, FP‐ssD@A‐E was the most significant. FP‐ssD@A‐E significantly decreased the cell viability and improved the Dox uptake. The levels of VEGFR‐1, P‐gp, IL‐6, and i‐NOS were significantly decreased after Dox, Dox + Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E treatment. It was worth noting that FP‐ssD@A‐E had the most significant effects. The prepared FP‐ssD@A‐E micelles, which were spherical in shape, uniform in particle size distribution, and had good drug loading performance and encapsulation efficiency. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1751-875X 1751-8741 |
العلاقة: | https://doaj.org/toc/1751-8741Test; https://doaj.org/toc/1751-875XTest |
DOI: | 10.1049/nbt2.12102 |
الوصول الحر: | https://doaj.org/article/37f344a0694843dfb4284ece6e85c60eTest |
رقم الانضمام: | edsdoj.37f344a0694843dfb4284ece6e85c60e |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 1751875X 17518741 |
---|---|
DOI: | 10.1049/nbt2.12102 |