دورية أكاديمية
High Prevalence of Antinuclear Antibodies in Children with Thyroid Autoimmunity
| العنوان: | High Prevalence of Antinuclear Antibodies in Children with Thyroid Autoimmunity |
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| المؤلفون: | SEGNI, Maria, TRUGLIA, SIMONA, CONTI, FABRIZIO, Ida Pucarelli, Ilaria Turriziani, Chiara Serafinelli |
| المساهمون: | Segni, Maria, Ida, Pucarelli, Truglia, Simona, Ilaria, Turriziani, Chiara, Serafinelli, Conti, Fabrizio |
| بيانات النشر: | HINDAWI PUBLISHING CORPORATION |
| سنة النشر: | 2014 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| الوصف: | Background. Antinuclear antibodies (ANA) are a hallmark of many autoimmune diseases and can be detected many years before disease onset. Autoimmune thyroid diseases (AITD) are frequently associated with other organ-and non-organ-specific autoimmune disorders. Objectives. To assess the prevalence of ANA in pediatric patients with AITD and their clinical correlations. Methods. Ninety-three consecutive pediatric patients with AITD were enrolled (86 children with chronic lymphocytic thyroiditis and 7 with Graves' disease). ANA, anti-double DNA (anti-dsDNA) antibodies, anti-extractable nuclear antigen (anti-ENA), anti-cyclic citrullinated peptide antibodies (anti-CCP), and rheumatoid factor (RF) was obtained. Signs and symptoms potentially related to rheumatic diseases in children were investigated by a questionnaire. Results. ANA positivity was found in 66/93 children (71%), anti-ENA in 4/93 (4.3%), anti-dsDNA in 1/93 (1.1%), RF in 3/93 (3.2%), and anti-CCP in none. No significant differences were found between the ANA-positive and ANA-negative groups with respect to age, sex, L-thyroxine treatment, or prevalence of other autoimmune diseases. Overall, parental autoimmunity was found in 23%. Conclusions. ANA positivity was demonstrated in 71% of children with AITD. ANA positivity was not related to overt immune-rheumatic diseases. However, because the positivity of ANA can occur even many years before the onset of systemic autoimmune diseases, prospective studies are warranted. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/24741574; info:eu-repo/semantics/altIdentifier/wos/WOS:000332536900001; volume:2014; numberofpages:6; journal:JOURNAL OF IMMUNOLOGY RESEARCH; http://hdl.handle.net/11573/559414Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84896950452 |
| DOI: | 10.1155/2014/150239 |
| الإتاحة: | https://doi.org/10.1155/2014/150239Test http://hdl.handle.net/11573/559414Test |
| رقم الانضمام: | edsbas.635028C2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2014/150239 |
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