Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage
| العنوان: | Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage |
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| المؤلفون: | Yan Guo, Junming Luo, Guirong Wang, Sara Javidiparsijani, Jingshi Liu, Honggang Liu, Jinwu Peng, Yichun Wang, Shukun Zhang |
| المصدر: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| بيانات النشر: | Hindawi Publishing Corporation, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Cartilage, Articular, Pathology, medicine.medical_specialty, Article Subject, lcsh:Medicine, Osteoarthritis, Cell Communication, Matrix (biology), Biology, General Biochemistry, Genetics and Molecular Biology, Extracellular matrix, Mice, medicine, Animals, Matrilin Proteins, Aggrecan, Stem cell transplantation for articular cartilage repair, Basement membrane, General Immunology and Microbiology, Cartilage, lcsh:R, General Medicine, medicine.disease, Extracellular Matrix, medicine.anatomical_structure, Gene Expression Regulation, Immunohistochemistry, Biomarkers, Research Article |
| الوصف: | In this study, we first generated and characterized a polyclonal antibody against unique domain of matrlin-2 and then used this specific antibody to assess the expression pattern of matrilin-2 by immunohistochemistry. We found that marilin-2 is widely distributed in the connective tissues of many mouse tissues including heart, colon, penis, esophagus, lung, kidney, tracheal cartilage, developmental bone, and adult bone. The expression level of matrilin-2 was remarkably increased in the tissues of osteoarthritis developmental articular cartilage, compared to normal healthy tissues. Furthermore, we determined matrilin-2 expression in specific epithelial cells in stomach and ductal epithelial cells of salivary gland. In other tissues, the positive signals were mainly located around cardiac muscle cells and Purkinje fibers in the heart; corpus spongiosum in the penis; submucosa in the colon and esophagus; extracellular matrix of cartilage in the tracheal cartilage; and, glomerulus, the basement membrane of distal convoluted tubule and renal matrix in kidney. These observations indicated that the distribution pattern of matrilin-2 is heterogeneous in each tissue. Matrilin-2 may play an important role in the communication of matrix to matrix and matrix to cells and will be used as a potential biomarker in the early stage of osteoarthritis of articular cartilage. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7a0110dec235ae076ce956ebeda580Test http://europepmc.org/articles/PMC3967717Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1a7a0110dec235ae076ce956ebeda580 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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