Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration
| العنوان: | Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration |
|---|---|
| المؤلفون: | Philippe Hantson, Xavier Wittebole, Nicolas De Schryver, Peter Van den Bergh, Vincent Haufroid, Eric Goffin |
| المساهمون: | UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Centre de référence neuromusculaire, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/NEFR-Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de biochimie médicale |
| المصدر: | Case Reports in Nephrology, Vol. 2015, p. 761393 [1-4] (2015) Case Reports in Nephrology, Vol 2015 (2015) Case Reports in Nephrology |
| بيانات النشر: | Hindawi Publishing Corporation, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | business.industry, nutritional and metabolic diseases, Case Report, Pharmacology, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, Ciprofloxacin, Nephrology, Simvastatin, Toxicity, Genetic predisposition, Medicine, lipids (amino acids, peptides, and proteins), Amlodipine, medicine.symptom, business, Myopathy, Rhabdomyolysis, Adverse drug reaction, medicine.drug |
| الوصف: | Simvastatin is among the most commonly used prescription medications for cholesterol reduction and the most common statin-related adverse drug reaction is skeletal muscle toxicity. Multiple factors have been shown to influence simvastatin-induced myopathy. In addition to age, gender, ethnicity, genetic predisposition, and dose, drug-drug interactions play a major role. This is particularly true for drugs that are extensively metabolized by cytochrome P450 (CYP)3A4. We describe a particularly severe case of rhabdomyolysis after the introduction of ciprofloxacin, a weak CYP3A4 inhibitor, in a patient who previously tolerated the simvastatin-amlodipine combination. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a335607cf331a7b35f0f60bbdb46d5bdTest https://hdl.handle.net/2078.1/158875Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a335607cf331a7b35f0f60bbdb46d5bd |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |