Rosuvastatin Counteracts Vessel Arterialisation and Sinusoid Capillarisation, Reduces Tumour Growth, and Prolongs Survival in Murine Hepatocellular Carcinoma
| العنوان: | Rosuvastatin Counteracts Vessel Arterialisation and Sinusoid Capillarisation, Reduces Tumour Growth, and Prolongs Survival in Murine Hepatocellular Carcinoma |
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| المؤلفون: | Jean-Olivier Contreres, Carole Le Henaff, Patricia Hainaud-Hakim, Caroline Gest, Bernard I. Levy, Annemilaï Tijeras-Raballand, Marc Pocard, Claudine Soria, Evelyne Dupuy |
| المصدر: | Gastroenterology Research and Practice Gastroenterology Research and Practice, Vol 2010 (2010) |
| بيانات النشر: | Hindawi Publishing Corporation, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Statin, Article Subject, medicine.drug_class, Sinusoid, Laminin, Medicine, Rosuvastatin, lcsh:RC799-869, Hepatology, biology, business.industry, Gastroenterology, nutritional and metabolic diseases, medicine.disease, digestive system diseases, Endothelial stem cell, medicine.anatomical_structure, Hepatocyte, Hepatocellular carcinoma, biology.protein, Hepatic stellate cell, lcsh:Diseases of the digestive system. Gastroenterology, business, medicine.drug, Research Article |
| الوصف: | Background and Aims. An arterial blood supply and phenotypic changes of the sinusoids characterise the liver vasculature in human hepatocellular carcinoma (HCC). We investigated the effects of rosuvastatin on liver vessel anomalies, tumour growth and survival in HCC.Methods. We treated transgenic mice developing HCC, characterized by vessel anomalies similar to those of human HCC, with rosuvastatin.Results. In the rosuvastatin group, the survival time was longer(P<.001), and liver weight(P<.01)and nodule surface(P<.01)were reduced. Rosuvastatin decreased the number of smooth muscle actin-positive arteries(P<.05)and prevented the sinusoid anomalies, with decreased laminin expression(P<.001), activated hepatic stellate cells(P<.001), and active Notch4 expression. Furthermore, rosuvastatin inhibited endothelial cell but not tumour hepatocyte functions.Conclusions. Rosuvastatin reduced the vessel anomalies and tumour growth and prolonged survival in HCC. These results represent new mechanisms of the effects of statin on tumour angiogenesis and a potential target therapy in HCC. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1687-630X 1687-6121 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f1e0a97a90aef2097cb6192073deedTest http://europepmc.org/articles/PMC3082163Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b3f1e0a97a90aef2097cb6192073deed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1687630X 16876121 |
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