Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models
| العنوان: | Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models |
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| المؤلفون: | Pallavi Sontakke, Jan Jacob Schuringa, Edo Vellenga, Jenny Jaques |
| المصدر: | Stem Cells International Stem Cells International, Vol 2016 (2016) |
| بيانات النشر: | Hindawi Publishing Corporation, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Internal medicine, medicine.drug_class, IMATINIB MESYLATE, Review Article, Biology, Tyrosine-kinase inhibitor, BCR/ABL TRANSGENIC MICE, 03 medical and health sciences, NOD/SCID MICE, In vivo, hemic and lymphatic diseases, MYELOPROLIFERATIVE DISEASE, medicine, HEMATOPOIETIC STEM-CELLS, Progenitor cell, lcsh:RC31-1245, BCR-ABL, Molecular Biology, ACUTE LYMPHOBLASTIC-LEUKEMIA, CHRONIC-PHASE, CHRONIC MYELOGENOUS LEUKEMIA, Myeloid leukemia, Cell Biology, COLONY-STIMULATING FACTOR, medicine.disease, Transplantation, 030104 developmental biology, medicine.anatomical_structure, Imatinib mesylate, Immunology, Bone marrow, Chronic myelogenous leukemia |
| الوصف: | Over the past years, a wide variety ofin vivomouse models have been generated in order to unravel the molecular pathology of Chronic Myeloid Leukemia (CML) and to develop and improve therapeutic approaches. These models range from (conditional) transgenic models, knock-in models, and murine bone marrow retroviral transduction models followed by transplantation. With the advancement of immunodeficient xenograft models, it has become possible to use human stem/progenitor cells forin vivostudies as well as cells directly derived from CML patients. These models not only mimic CML but also have been instrumental in uncovering various fundamental mechanisms of CML disease progression and tyrosine kinase inhibitor (TKI) resistance. With the availability of iPSC technology, it has become feasible to derive, maintain, and expand CML subclones that are at least genetically identical to those in patients. The following review provides an overview of all murine as well as human xenograft models for CML established till date. |
| اللغة: | English |
| تدمد: | 1687-9678 1687-966X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40163394af90c050b83446cf8e0a5cafTest http://europepmc.org/articles/PMC5014953Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....40163394af90c050b83446cf8e0a5caf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16879678 1687966X |
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