The Protection of Salidroside of the Heart against Acute Exhaustive Injury and Molecular Mechanism in Rat
| العنوان: | The Protection of Salidroside of the Heart against Acute Exhaustive Injury and Molecular Mechanism in Rat |
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| المؤلفون: | Haiyan Liu, Peng Xu, Yang Wang, Xuebin Cao, Yuwen Zhou, Yunru Wang |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2013 (2013) |
| بيانات النشر: | Hindawi Publishing Corporation, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | MAPK/ERK pathway, Male, Aging, medicine.medical_specialty, Cardiotonic Agents, Article Subject, p38 mitogen-activated protein kinases, Ischemia, In Vitro Techniques, Biochemistry, p38 Mitogen-Activated Protein Kinases, Superoxide dismutase, Rats, Sprague-Dawley, chemistry.chemical_compound, Glucosides, Phenols, Internal medicine, Malondialdehyde, Physical Conditioning, Animal, medicine, Animals, Creatine Kinase, MB Form, Myocytes, Cardiac, lcsh:QH573-671, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Cell Shape, Cardioprotection, biology, L-Lactate Dehydrogenase, lcsh:Cytology, Superoxide Dismutase, Myocardium, Salidroside, Cell Biology, General Medicine, medicine.disease, Rats, Endocrinology, chemistry, Heart Function Tests, biology.protein, Creatine kinase, Research Article |
| الوصف: | Objective. To investigate the protection of salidroside of the heart against acute exhaustive injury and its mechanism of antioxidative stress and MAPKs signal transduction.Method. Adult male SD rats were divided into four groups randomly. Cardiomyocytes ultrastructure was observed by optical microscopy and transmission electron microscopy. The contents of CK, CK-MB, LDH, MDA, and SOD were determined by ELISA method, and the phosphorylation degrees of ERK and p38 MAPK were assayed by Western blotting. Cardiac function of isolated rat heart ischemia/reperfusion was detected by Langendorff technique.Results. Salidroside reduced the myocardium ultrastructure injury caused by exhaustive swimming, decreased the contents of CK, CK-MB, and LDH, improved the LVDP, ±LV dp/dtmaxunder the basic condition, reduced the content of MDA and the phosphorylation degree of p38 MAPK, and increased the content of SOD and the phosphorylation degree of ERK in acute exhaustive rats.Conclusion. Salidroside has the protection of the heart against acute exhaustive injury. The cardioprotection is mainly mediated by antioxidative stress and MAPKs signal transduction through reducing the content of MDA, increasing the content of SOD, and increasing p-ERK and decreasing p-p38 protein expressions in rat myocardium, which might be the mechanisms of the cardioprotective effect of salidroside. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1942-0994 1942-0900 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6074be8435eea979bd6536694dee109cTest http://europepmc.org/articles/PMC3880758Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6074be8435eea979bd6536694dee109c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
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