Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis
| العنوان: | Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis |
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| المؤلفون: | Chien-Ming Chao, Bor-Chih Cheng, Ching-Ping Chang, Chung-Zhing Yang, Chung-Ching Chio, Chong-Un Cheong |
| المصدر: | Mediators of Inflammation Mediators of Inflammation, Vol 2013 (2013) |
| بيانات النشر: | Hindawi Publishing Corporation, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | musculoskeletal diseases, Male, Pathology, medicine.medical_specialty, Doublecortin Protein, Article Subject, Traumatic brain injury, Neurogenesis, Immunology, Receptors, Tumor Necrosis Factor, Etanercept, Cerebral contusion, Immunoenzyme Techniques, Rats, Sprague-Dawley, Random Allocation, lcsh:Pathology, Medicine, Animals, Receptor, skin and connective tissue diseases, biology, business.industry, Tumor Necrosis Factor-alpha, Cell Biology, medicine.disease, Doublecortin, Rats, nervous system, Anesthesia, Brain Injuries, Immunoglobulin G, biology.protein, Systemic administration, Tumor necrosis factor alpha, business, lcsh:RB1-214, medicine.drug, Research Article |
| الوصف: | It remains unclear whether etanercept penetrates directly into the contused brain and improves the outcomes of TBI by attenuating brain contents of TNF-αand/or stimulating newly formed neurogenesis. Rats that sustained TBI are immediately treated with etanercept. Acute neurological and motor injury is assessed in all rats the day prior to and 7 days after surgery. The numbers of the colocalizations of 5-bromodeoxyuridine and doublecortin specific markers in the contused brain injury that occurred during TBI were counted by immunofluorescence staining. Enzyme immunoassay for quantitative determination of TNF-αor etanercept in brain tissues is also performed. Seven days after systemic administration of etanercept, levels of etanercept can be detected in the contused brain tissues. In addition, neurological and motor deficits, cerebral contusion, and increased brain TNF-αcontents caused by TBI can be attenuated by etanercept therapy. Furthermore, the increased numbers of the colocalizations of 5-bromodeoxyuridine and doublecortin specific markers in the contused brain tissues caused by TBI can be potentiated by etanercept therapy. These findings indicate that systemically administered etanercept may penetrate directly into the contused brain tissues and may improve outcomes of TBI by reducing brain contents of TNF-αand by stimulating newly formed neurogenesis. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1466-1861 0962-9351 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5783e5c67314f80dc0e94dec05a4d1Test http://europepmc.org/articles/PMC3654326Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9d5783e5c67314f80dc0e94dec05a4d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14661861 09629351 |
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