دورية أكاديمية
Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus H체rthle Cell Neoplasms: A Retrospective Analysis
| العنوان: | Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus H체rthle Cell Neoplasms: A Retrospective Analysis |
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| المساهمون: | College of Medicine, Dept. of Pathology, Hye Min Kim, Ja Seung Koo, Koo, Ja Seung, Kim, Hye Min |
| بيانات النشر: | Hindawi Pub. Corp. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adenoma/genetics, Adenoma/metabolism, Adenoma, Oxyphilic/genetics, Oxyphilic/metabolism, Carbonic Anhydrase IX/genetics, Carbonic Anhydrase IX/metabolism, Carcinoma/genetics, Carcinoma/metabolism, Female, Glucose Transporter Type 1/genetics, Glucose Transporter Type 1/metabolism, Glycolysis, Hexokinase/genetics, Hexokinase/metabolism, Humans, Male, Middle Aged, Monocarboxylic Acid Transporters/genetics, onocarboxylic Acid Transporters/metabolism, Muscle Proteins/genetics, Muscle Proteins/metabolism, Thyroid Neoplasms/genetics, Thyroid Neoplasms/metabolism |
| الوصف: | PURPOSE: Although currently classified as variants of follicular neoplasms (FNs), H체rthle cell neoplasms (HCNs) exhibit distinct biological characteristics. Hence, the metabolism of both neoplasms may also be different. The aims of this study were to investigate and compare the expression of glycolysis-related proteins in HCNs and FNs and to determine the clinical implications of such expression. METHODS: Tissue microarrays were constructed with 265 samples of FNs (112 follicular carcinomas (FCs) and 153 follicular adenomas (FAs)) as well as 108 samples of HCNs (27 H체rthle cell carcinomas (HCCs) and 81 H체rthle cell adenomas (HCAs)). Immunohistochemical staining for the glycolysis-related molecules Glut-1, hexokinase II, CAIX, and MCT4 was performed. RESULTS: The expression levels of Glut-1, hexokinase II, CAIX, and MCT4 were significantly higher in HCNs than in FNs (p < 0.001). Glut-1, hexokinase II, CAIX, and MCT4 expression levels were highest in HCC, followed by HCA, FC, and FA (all p < 0.001). In HCC, hexokinase II positivity was associated with large tumor size (>4�뎑m) (p = 0.046), CAIX positivity with vascular invasion (p = 0.005), and MCT4 positivity with extrathyroidal extension (p = 0.030). CONCLUSION: The expression levels of the glycolysis-related proteins Glut-1, hexokinase II, CAIX, and MCT4 were higher in HCNs than in FNs and in HCCs than in HCAs. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0278-0240 1875-8630 |
| العلاقة: | DISEASE MARKERS; J00743; OAK-2017-03317; https://ir.ymlib.yonsei.ac.kr/handle/22282913/160356Test; T201702172; DISEASE MARKERS, Vol.2017 : 6230294, 2017 |
| DOI: | 10.1155/2017/6230294 |
| الإتاحة: | https://doi.org/10.1155/2017/6230294Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/160356Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.E18737A1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02780240 18758630 |
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| DOI: | 10.1155/2017/6230294 |