دورية أكاديمية
Alterations in the Blood Parameters and Fecal Microbiota and Metabolites during Pregnant and Lactating Stages in Bama Mini Pigs as a Model
العنوان: | Alterations in the Blood Parameters and Fecal Microbiota and Metabolites during Pregnant and Lactating Stages in Bama Mini Pigs as a Model |
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المؤلفون: | Cui Ma, QianKun Gao, WangHong Zhang, Md. Abul Kalam Azad, XiangFeng Kong |
المصدر: | Mediators of Inflammation, Vol 2020 (2020) |
بيانات النشر: | Hindawi Limited, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Pathology |
مصطلحات موضوعية: | Pathology, RB1-214 |
الوصف: | This study was conducted to analyze plasma reproductive hormone and biochemical parameter changes, as well as fecal microbiota composition and metabolites in sows, at different pregnancy and lactation stages, using Bama mini pig as an experimental animal model. We found that plasma prolactin (PRL), progesterone, follicle-stimulating hormone (FSH), and estrogen levels decreased from day 45 to day 105 of pregnancy. Plasma total protein and albumin levels were lower in pregnant sows, while glucose, urea nitrogen, total cholesterol, and high-density lipoprotein-cholesterol, as well as fecal acetate, butyrate, valerate, total short-chain fatty acids, skatole, and tyramine levels, were higher in lactating sows. Interestingly, the lactating sows showed lower α-diversity and Spirochaetes and Verrucomicrobia relative abundances, while pregnant sows showed a higher Proteobacteria relative abundance. Notably, the Akkermansia relative abundance was highest on day 7 of lactation. Spearman analysis showed a positive correlation between plasma triglyceride and cholinesterase levels and Akkermansia and Streptococcus relative abundances. Moreover, Oscillospira and Desulfovibrio relative abundances were also positively correlated with plasma FSH, LH, and E2 levels, as well as PRL and LH with Bacteroides. Collectively, plasma reproductive hormones, biochemical parameters, and fecal microbiota composition and metabolite levels could alter along with pregnancy and lactation, which might contribute to the growth and development demands of fetuses and newborns. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 0962-9351 1466-1861 |
العلاقة: | https://doaj.org/toc/0962-9351Test; https://doaj.org/toc/1466-1861Test |
DOI: | 10.1155/2020/8829072 |
الوصول الحر: | https://doaj.org/article/66d0ae31adf64ef2b235f4849a4f7346Test |
رقم الانضمام: | edsdoj.66d0ae31adf64ef2b235f4849a4f7346 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 09629351 14661861 |
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DOI: | 10.1155/2020/8829072 |