التفاصيل البيبلوغرافية
| العنوان: |
Pulmonary vein isolation with concomitant renal artery denervation is associated with reduction in both arterial blood pressure and atrial fibrillation burden: Data from implantable cardiac monitor. |
| المؤلفون: |
Romanov, Alexander, Pokushalov, Evgeny, Ponomarev, Dmitry, Strelnikov, Artem, Shabanov, Vitaliy, Losik, Denis, Karaskov, Alexander, Steinberg, Jonathan S. |
| المصدر: |
Cardiovascular Therapeutics; Aug2017, Vol. 35 Issue 4, pn/a-N.PAG, 7p |
| مصطلحات موضوعية: |
ABLATION techniques, ATRIAL fibrillation, RENAL artery obstruction, PULMONARY veins, DENERVATION, HYPERTENSION, BLOOD pressure, SURGERY |
| مستخلص: |
Background Renal artery denervation ( RDN) has provided incremental atrial fibrillation ( AF) suppression after pulmonary vein isolation ( PVI) in patients with AF in the setting of drug-resistant hypertension. Objective To assess the relationship between changes of mean blood pressure ( BP) and AF recurrences/ AF burden after PVI combined with RDN. Methods All patients from two randomized studies with symptomatic paroxysmal AF and/or persistent AF and resistant hypertension who underwent PVI-only (n=37) or PVI with RDN (n=39), and implantable cardiac monitor ( ICM) implantation were eligible for this study. Mixed-effects linear models were used to investigate the effect of RDN on mean BP and mean AF burden and associations between the two during the 12-month follow-up. Results Concomitant RDN was associated with a significant reduction in both mean AF burden (2.43 [95% CI: 1.76-3.09] % vs 6.95 [95% CI: 5.44-8.45] %) and mean BP (104 [95% CI: 103-106] mm Hg vs 112 [95% CI: 110-113] mm Hg). Decrease in mean BP was positively correlated with decline in mean AF burden: reduction of 5-10 mm Hg was accompanied by a 7.0% decreased mean AF burden, with greater reduction (up to 20 mm Hg) associated with on average 17.7% lower mean AF burden. Conclusions Renal artery denervation when added to PVI decreases AF recurrences, AF burden, and mean BP. Reduction in mean BP is associated with both AF burden and recurrences. Further large-scale studies are needed to define the mechanistic pathway(s) of the antiarrhythmic effects of RDN. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cardiovascular Therapeutics is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder