التفاصيل البيبلوغرافية
| العنوان: |
Rosiglitazone is effective and well-tolerated in a range of therapeutic regimens during daily practice in patients with type 2 diabetes. |
| المؤلفون: |
ROSAK, C., STANDL, E., REBLIN, T., STAMMER, H., SEIDEL, D. K. |
| المصدر: |
International Journal of Clinical Practice; Sep2006, Vol. 60 Issue 9, p1040-1047, 8p, 2 Charts, 2 Graphs |
| مصطلحات موضوعية: |
DIABETES, HYPOGLYCEMIC sulfonylureas, BLOOD sugar, GLYCEMIC index, THERAPEUTICS, BLOOD pressure |
| مستخلص: |
Subjects ( N = 22,808) with inadequately controlled type 2 diabetes mellitus (T2DM) were included in a large 6-month observational study in Germany. Rosiglitazone (RSG) was added to existing therapy in line with daily practice, with 19,962 subjects evaluated for efficacy by treatment group: RSG monotherapy ( n = 1017), RSG plus metformin (MET) ( n = 7160), RSG plus sulphonylurea ( n = 5033), triple oral therapy ( n = 4247), and the remaining subject population ( n = 2505). Overall, RSG significantly reduced median HbA1c and fasting blood glucose by 1.3% and 50 mg/dl over 6 months (p < 0.001 for both). The proportion of subjects achieving glycaemic goals of ≤ 6.5% and ≤ 7.0% increased from 5.7% to 33.8%, and from 13.9% to 55.5%, respectively (p < 0.001 for both). Mean systolic and diastolic blood pressures were reduced in the total subject population by 6 mmHg and 2 mmHg, respectively (p < 0.001 for both). RSG had a neutral or reductive effect on mean weight of most (69%) subjects. Consistent with clinical trial data, RSG mono- or combination therapy improved glycaemic control when used in daily clinical practice and is generally well-tolerated. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
