Alarming increase in ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes during the first wave of the COVID ‐19 pandemic in Israel
| العنوان: | Alarming increase in ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes during the first wave of the |
|---|---|
| المؤلفون: | Shira Goldman, Orit Pinhas‐Hamiel, Adi Weinberg, Adi Auerbach, Alina German, Alon Haim, Amnon Zung, Avivit Brener, David Strich, Erez Azoulay, Floris Levy‐Khademi, Hanna Ludar, Ilana Koren, Marianna Rachmiel, Michal Yackobovitch‐Gavan, Nehama Zuckerman‐Levin, Odeya David, Rana Halloun, Ranit Cahn, Tal Ben‐Ari, Yonatan Yeshayahu, Zohar Landau, Moshe Phillip, Yael Lebenthal |
| المصدر: | Web of Science |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Adolescent, SARS-CoV-2, Incidence, Endocrinology, Diabetes and Metabolism, COVID-19, Comorbidity, Diabetic Ketoacidosis, Diabetes Mellitus, Type 1, Population Surveillance, Pediatrics, Perinatology and Child Health, Internal Medicine, Humans, Female, Israel, Child, Pandemics, Follow-Up Studies, Retrospective Studies |
| الوصف: | To evaluate the incidence and severity of ketoacidosis (DKA) at type 1 diabetes diagnosis during the first wave of the coronavirus disease 2019 (COVID-19) pandemic in Israel.A population-based study the product of a national collaboration of Israeli pediatric diabetes centers investigated the presentation of childhood-onset type 1 diabetes. The frequencies of DKA and severe DKA observed during the COVID-19 period from March 15, 2020 (commencement of the first nationwide lockdown) until June 30, 2020 were compared with the same periods in 2019, 2018, and 2017 using multivariable logistic regression, adjusting for age, sex, and socioeconomic position.During the COVID-19 period, DKA incidence was 58.2%, significantly higher than in 2019 (adjusted OR [aOR] 2.18 [95% CI, 1.31-3.60], P = 0.003); 2018 (aOR 2.05 [95% CI, 1.26-3.34], P = 0.004); and 2017 (aOR, 1.79 [95% CI, 1.09-2.93], P = 0.022). The incidence of severe DKA was 19.9%, significantly higher than in 2018 (aOR, 2.49 [95% CI, 1.20-5.19], P = 0.015) and 2017 (aOR, 2.73 [95% CI, 1.28-5.82], P = 0.009). In 2020, admissions and duration of stay in the intensive care unit were higher than in previous years (P = 0.001). During the COVID-19 pandemic, children aged 6-11 years had higher incidences of DKA (61.3% vs. 34.0%, 40.6%, and 45.1%, respectively, P = 0.012), and severe DKA (29.3% vs. 15.1%, 10.9%, and 5.9%, respectively, P = 0.002).The dramatic increase in DKA at presentation of childhood-onset type 1 diabetes during the COVID-19 pandemic mandates targeted measures to raise public and physician awareness. |
| تدمد: | 1399-5448 1399-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1944bb15b4ec97cf8c4dd80c0f8b6ae5Test https://doi.org/10.1111/pedi.13296Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1944bb15b4ec97cf8c4dd80c0f8b6ae5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13995448 1399543X |
|---|