A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee
| العنوان: | A Novel Framework for the Identification and Analysis of Duplicons between Human and Chimpanzee |
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| المؤلفون: | Yao-Ting Huang, Trees-Juen Chuang, Shian-Zu Wu |
| المصدر: | BioMed Research International BioMed Research International, Vol 2013 (2013) |
| بيانات النشر: | Hindawi Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | DNA Copy Number Variations, Pan troglodytes, Non-allelic homologous recombination, lcsh:Medicine, Biology, Genome, General Biochemistry, Genetics and Molecular Biology, Segmental Duplications, Genomic, Species Specificity, Phylogenetics, Gene duplication, Animals, Cluster Analysis, Humans, Copy-number variation, Homologous Recombination, Phylogeny, Segmental duplication, Genetics, General Immunology and Microbiology, Phylogenetic tree, Mosaicism, Methodology Report, lcsh:R, Molecular Sequence Annotation, General Medicine, Chromosomes, Mammalian, Markov Chains, Evolutionary biology, Human genome |
| الوصف: | Human and other primate genomes consist of many segmental duplications (SDs) due to fixation of copy number variations (CNVs). Structure of these duplications within the human genome has been shown to be a complex mosaic composed of juxtaposed subunits (called duplicons). These duplicons are difficult to be uncovered from the mosaic repeat structure. In addition, the distribution and evolution of duplicons among primates are still poorly investigated. In this paper, we develop a statistical framework for discovering duplicons via integration of a Hidden Markov Model (HMM) and a permutation test. Our comparative analysis indicates that the mosaic structure of duplicons is common in CNV/SD regions of both human and chimpanzee genomes, and a subset of core duplicons is shared by the majority of CNVs/SDs. Phylogenetic analyses using duplicons suggested that most CNVs/SDs share common duplication ancestry. Many human/chimpanzee duplicons flank both ends of CNVs, which may be hotspots of nonallelic homologous recombination. |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e570dc5e36fd18deae39927ea1d6e8Test https://doi.org/10.1155/2013/264532Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....19e570dc5e36fd18deae39927ea1d6e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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