المؤلفون: Sandner, Sigrid¹ (AUTHOR), Salerno, Tomas² (AUTHOR), Gaudino, Mario F. L.³ (AUTHOR) mfg9004@med.cornell.edu

المصدر: Journal of Cardiac Surgery. Dec2021, Vol. 36 Issue 12, p4456-4459. 4p. 1 Color Photograph.

المؤلفون: Sandner, Sigrid¹ (AUTHOR) sigrid.sandner@meduniwien.ac.at, Gaudino, Mario² (AUTHOR), Kastrati, Adnan³ (AUTHOR)

المصدر: Journal of Cardiac Surgery. Apr2022, Vol. 37 Issue 4, p1087-1089. 3p. 1 Graph.

مستخلص: Indeed, the majority of contemporary randomized trials that included imaging follow-up at 1 year have failed to demonstrate a significant benefit of intensified antithrombotic therapy including oral anticoagulation on SVG patency over aspirin5,6,12-14 (Figure 1). Keywords: coronary artery disease; patency; saphenous vein graft; ticagrelor EN coronary artery disease patency saphenous vein graft ticagrelor 1087 1089 3 03/02/22 20220401 NES 220401 Saphenous vein grafts (SVGs) remain the most commonly used conduits in coronary artery bypass grafting (CABG) despite greater rates of both early and late occlusion compared to arterial grafts. In a recent meta-analysis based on aggregate data from 48 studies including 41,530 grafts, the pooled incidence of SVG occlusion within the first year after CABG was estimated at 11%.1 The role of aspirin in the prevention of SVG failure has been firmly established. [Extracted from the article]

المؤلفون: Wollner, Gregor, Zimpfer, Daniel, Manduric, Marina, Laufer, Günther, Rieger, Armin, Sandner, Sigrid E.

المصدر: Journal of Cardiac Surgery; Oct2020, Vol. 35 Issue 10, p2543-2549, 7p, 5 Charts, 3 Graphs

مصطلحات موضوعية: HIV infections, CORONARY artery bypass, HIGHLY active antiretroviral therapy, HIV infection complications, STROKE, SURGICAL complications, CARDIOVASCULAR diseases, RETROSPECTIVE studies, MYOCARDIAL infarction, TREATMENT effectiveness, CORONARY artery disease, DISEASE complications

الشركة/الكيان: MEDIZINISCHE Universitat Wien

مستخلص: Background: With early and effective antiretroviral therapy and improved survival for persons living with human immunodeficiency virus infection (PLHIV), this patient population now faces an increasingly elevated risk of cardiovascular disease. However, the data on outcomes after coronary artery bypass grafting (CABG) for revascularization of coronary artery disease (CAD) in HIV+ patients is limited.Methods: We conducted a retrospective analysis of 16 patients undergoing isolated CABG at the Medical University of Vienna from 2005 to 2018, who were HIV+ on admission. The primary endpoint of the study was survival. Secondary endpoints included the components of major adverse cardiac and cerebrovascular events (MACCE): cardiovascular death, stroke, myocardial infarction (MI), and repeat revascularization.Results: Patients were followed for a median of 49 months (range, 7-142 months). Survival was 100% and 90% at 1 and 3 years after CABG, respectively. There were no strokes. MI and subsequent repeat revascularization were observed in two patients.Conclusion: CABG provides excellent short- and midterm survival and freedom from MACCE in HIV+ patients with CAD requiring revascularization. [ABSTRACT FROM AUTHOR]

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المؤلفون: Sandner, Sigrid¹ (AUTHOR), Gaudino, Mario² (AUTHOR) mfg9004@med.cornell.edu

المصدر: Journal of Cardiac Surgery. Aug2021, Vol. 36 Issue 8, p2802-2804. 3p.

مصطلحات موضوعية: *ACUTE coronary syndrome, *TICAGRELOR, *CORONARY artery bypass, *MYOCARDIAL infarction, *ATHEROSCLEROSIS, *REOPERATION, *CORONARY artery disease

مستخلص: Given the lack of established benefit, routine P2Y12 receptor inhibitor pretreatment in NSTE-ACS is not recommended in patients in whom the coronary anatomy is not known and early invasive management is planned, although it may be considered for patients with delayed invasive management.3 However, P2Y12 receptor inhibitor pretreatment may increase bleeding risk and delay surgery after diagnostic angiography in patients for whom CABG is indicated. In addition, in studies investigating the association of P2Y12 receptor inhibitors and perioperative bleeding risk a surgical bleeding site was identified in up to 55% of patients undergoing reoperation for bleeding,5,14 potentially confounding reports of increased bleeding with ticagrelor. Hansson et al.10 studied the incidence of CABG-related bleeding using the Bleeding Academic Research Consortium (BARC) classification11 in relation to P2Y12 receptor inhibitor discontinuation periods in a retrospective analysis of 2244 ACS patients referred for CABG on DAPT with either ticagrelor or clopidogrel. [Extracted from the article]

المؤلفون: Sandner, Sigrid¹ (AUTHOR) sigrid.sandner@meduniwien.ac.at, Ruel, Marc² (AUTHOR)

المصدر: Journal of Cardiac Surgery. Nov2022, Vol. 37 Issue 11, p3673-3674. 2p.

مصطلحات موضوعية: *SAPHENOUS vein, *VASCULAR grafts, *VASCULAR resistance, PREVENTION of surgical complications, DISEASE relapse prevention

مستخلص: Keywords: secondary prevention; vein graft disease; vein graft failure EN secondary prevention vein graft disease vein graft failure 3673 3674 2 10/13/22 20221101 NES 221101 Coronary artery bypass grafting (CABG) is the treatment of choice for patients with complex coronary artery disease. 9 Kulik A, Abreu AM, Boronat V, Ruel M. Intensive versus moderate statin therapy and early graft occlusion after coronary bypass surgery: the aggressive cholesterol therapy to inhibit vein graft events randomized clinical trial. Association of dual antiplatelet therapy with ticagrelor with vein graft failure after coronary artery bypass graft surgery: a systematic review and meta-analysis. [Extracted from the article]

المؤلفون: Sandner, Sigrid¹ (AUTHOR) sigrid.sandner@meduniwien.ac.at, Redfors, Björn² (AUTHOR)

المصدر: Journal of Cardiac Surgery. Jul2022, Vol. 37 Issue 7, p1978-1979. 2p.

مستخلص: Notably, only 4 new SVG occlusions and 2 new SVG stenoses occurred between years 1 and 2, with no significant differences between the treatment arms ( I p i = .41). The rate of SVG occlusion in the 142 patients who consented to the extended study and underwent imaging at 2 years after CABG did not differ significantly between the treatment groups (ticagrelor 13.2%, aspirin 15.7%, I p i = .71). Keywords: coronary artery bypass; patency; saphenous vein graft; ticagrelor EN coronary artery bypass patency saphenous vein graft ticagrelor 1978 1979 2 06/06/22 20220701 NES 220701 The Ticagrelor Antiplatelet therapy to Reduce Graft Events and Thrombosis (TARGET) trial randomized 250 patients after coronary artery bypass grafting (CABG) to ticagrelor monotherapy or aspirin monotherapy. [Extracted from the article]