Influence of Interleukin IL-2 and IL-12 + IL-18 on Surface Expression of Immunoglobulin-Like Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells
| العنوان: | Influence of Interleukin IL-2 and IL-12 + IL-18 on Surface Expression of Immunoglobulin-Like Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells |
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| المؤلفون: | Sławomir Chrul, Ewa Polakowska, Agnieszka Szadkowska, Jerzy Bodalski |
| المصدر: | Mediators of Inflammation, Vol 2006 (2006) Mediators of Inflammation |
| بيانات النشر: | Hindawi Limited, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, Immunology, CD1, Fluorescent Antibody Technique, chemical and pharmacologic phenomena, Immune receptor, Biology, Natural killer cell, Research Communication, Interleukin 21, Receptors, KIR, lcsh:Pathology, medicine, Humans, Receptors, Immunologic, Child, Cells, Cultured, Lymphokine-activated killer cell, ZAP70, Interleukin-18, Receptors, KIR3DL2, Cell Biology, Flow Cytometry, Natural killer T cell, Interleukin-12, Cell biology, Killer Cells, Natural, medicine.anatomical_structure, Child, Preschool, Receptors, KIR2DL2, Receptors, KIR2DL1, Interleukin 12, Interleukin-2, Female, lcsh:RB1-214 |
| الوصف: | Natural killer (NK) cells express killer cell inhibitory receptors (KIRs) that recognize polymorphic class I MHC molecules. In the present study, we analyze the modulatory effect of IL-2 alone or a combination of IL-12 with IL-18 on surface expression of killer cell immunoglobulin-like receptors KIR2DL1, KIR2DL2, and KIR3DL2 in NK cells. Thus, it was found that IL-2 causes a significant increase in the proportion of cells with given studied receptors. Stimulation by a mixture of IL-12 and IL-18 caused significant increase in the fraction of cells with the KIR2DL1 and KIR2DL2, however no significant change in the percentage of cells with KIR3DL2 receptor on their surface was observed. The results of the study show the presence of KIRs on both resting and activated NK cells, this may suggest that KIRs have also an important role in the regulatory processes after activation of this subpopulation of cells. |
| تدمد: | 1466-1861 0962-9351 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f4a28bc220ce09379a4ff366a9902fTest https://doi.org/10.1155/mi/2006/46957Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....24f4a28bc220ce09379a4ff366a9902f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14661861 09629351 |
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