دورية أكاديمية
Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRL/lpr Mice
| العنوان: | Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRL/lpr Mice |
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| المؤلفون: | Jiali Zhu, Kui Cui, Jianqun Kou, Shuzhi Wang, Yinli Xu, Zhihui Ding, Rong Han, Zhenghong Qin |
| المصدر: | Evidence-Based Complementary and Alternative Medicine, Vol 2014 (2014) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2014 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Other systems of medicine, RZ201-999 |
| الوصف: | Systemic lupus erythematosus (SLE) is an autoimmune disease and effective therapy for this pathology is currently unavailable. We previously reported that oral administration of Naja naja atra venom (NNAV) had anti-inflammatory and immune regulatory actions. We speculated that NNAV may have therapeutic effects in MRL/lpr SLE mice. Twelve-week-old MRL/lpr mice received oral administration of NNAV (20, 40, and 80 μg/kg) or Tripterygium wilfordii polyglycosidium (10 mg/kg) daily for 16 weeks. The effects of NNAV on SLE manifestations, including skin erythema, proteinuria, and anxiety-like behaviors, were assessed with visual inspection and Multistix 8 SG strips and open field test, respectively. The pathology of spleen and kidney was examined with H&E staining. The changes in autoimmune antibodies and cytokines were determined with ELISA kits. The results showed that NNAV protected against the manifestation of SLE, including skin erythema and proteinuria. In addition, although no apparent histological change was found in liver and heart in MRL/lpr SLE mice, NNAV reduced the levels of glutamate pyruvate transaminase and creatine kinase. Furthermore, NNAV increased serum C3 and reduced concentrations of circulating globulin, anti-dsDNA antibody, and inflammatory cytokines IL-6 and TNF-α. NNAV also reduced lymphadenopathy and renal injury. These results suggest that NNAV may have therapeutic values in the treatment of SLE by inhibiting autoimmune responses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1741-427X 1741-4288 |
| العلاقة: | http://dx.doi.org/10.1155/2014/969482Test; https://doaj.org/toc/1741-427XTest; https://doaj.org/toc/1741-4288Test; https://doaj.org/article/aefb86adc1574267a1dc71d34fda9a9aTest |
| DOI: | 10.1155/2014/969482 |
| الإتاحة: | https://doi.org/10.1155/2014/969482Test https://doaj.org/article/aefb86adc1574267a1dc71d34fda9a9aTest |
| رقم الانضمام: | edsbas.D285406D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1741427X 17414288 |
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| DOI: | 10.1155/2014/969482 |