دورية أكاديمية
Are Breast Cancer Molecular Classes Predictive of Survival in Patients with Long Follow-Up?
| العنوان: | Are Breast Cancer Molecular Classes Predictive of Survival in Patients with Long Follow-Up? |
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| المؤلفون: | Danae Pracella, Serena Bonin, Renzo Barbazza, Anna Sapino, Isabella Castellano, Sandro Sulfaro, Giorgio Stanta |
| المصدر: | Disease Markers, Vol 35, Iss 6, Pp 595-605 (2013) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2013 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | In this study we investigate the clinical outcomes of 305 breast cancer (BC) patients, aged 55 years or younger, with long follow-up and according to intrinsic subtypes. The cohort included 151 lymph node negative (LN−) and 154 lymph node positive (LN+) patients. Luminal A tumors were mainly LN−, well differentiated, and of stage I; among them AR was an indicator of good prognosis. Luminal B and HER2 positive nonluminal cancers showed higher tumor grade and nodal metastases as well as higher proliferation status and stage. Among luminal tumors, those PR positive and vimentin negative showed a longer survival. HER2-positive nonluminal and TN patients showed a poorer outcome, with BC-specific death mostly occurring within 5 and 10 years. Only luminal tumor patients underwent BC death over 10 years. When patients were divided in to LN− and LN+ no differences in survival were observed in the luminal subgroups. LN− patients have good survival even after 20 years of follow-up (about 75%), while for LN+ patients survival at 20 years (around 40%) was comparable to HER2-positive nonluminal and TN groups. In conclusion, in our experience ER-positive breast tumors are better divided by classical clinical stage than molecular classification, and they need longer clinical follow-up especially in cases with lymph node involvement. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0278-0240 1875-8630 |
| العلاقة: | http://dx.doi.org/10.1155/2013/347073Test; https://doaj.org/toc/0278-0240Test; https://doaj.org/toc/1875-8630Test; https://doaj.org/article/3588c6c708a04651af737f242aa0a9c9Test |
| DOI: | 10.1155/2013/347073 |
| الإتاحة: | https://doi.org/10.1155/2013/347073Test https://doaj.org/article/3588c6c708a04651af737f242aa0a9c9Test |
| رقم الانضمام: | edsbas.2931C4B7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02780240 18758630 |
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| DOI: | 10.1155/2013/347073 |